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Anesth Analg 1931; 10:112-122
© 1931 International Anesthesia Research Society
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Experimental Anesthesia with Tri-Brom-Ethyl-Alcohol (Avertin) and Sodium Iso-Amyl-Ethyl-Barbiturate (Sodium Amytal.)*

Adolph Bolliger, Ph.D, and Kempson Maddox, M.B., M.R.C.P

Sydney Australia.

Abstract

DURING THE COURSE of an investigation of nephritis in dogs and puppies, we became dissatisfied with inhalation anesthesia under which the frequency of bronchopneumonia considerably restricted our material, aided, probably, by the preliminary resection of the vocal cords necessary to quiet dogs when quartered near hospital wards. The first and natural alternative which suggested itself was induction of anesthesia by the rectal route. A trial was made of Gwathmey's oil-ether technique in the dosage recommended by him for dogs,1 but this seems a complicated procedure besides requiring beforehand a large depressant dose of raorphin. Avertin (tri-brom-ethyl alcohol) became available locally about this time and led us to make trials of experimental anesthesia with this new drug.

Before this work was concluded, we were also furnished with a supply of sodium amytal (sodium iso-amyl-ethyl-barbiturate), a white powder soluble in distilled water which has been used in the United States of America as an intravenous narcotic. We therefore decided to test the suitability or otherwise of this substance for our work and to criticize it according to the standards we had already applied to avertin.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1931 by the International Anesthesia Research Society.