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REGIONAL ANESTHESIA

Continuous Thoracic Epidural Anesthesia Induces Segmental Sympathetic Block in the Awake Rat

Department of Anesthesiology and Intensive Care Medicine, University Hospital of Muenster, Muenster, Germany

Address correspondence and reprint requests to Hendrik Freise, Department of Anesthesiology and Intensive Care Medicine, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany. Address e-mail to freiseh{at}uni-muenster.de

Thoracic epidural anesthesia (TEA) is used increasingly in critical care, especially for cardiac and intestinal sympathetic block. In this study we evaluated cardiorespiratory function and sympathetic activity in a new model of continuous TEA in awake rats. Thirteen rats received epidural saline control (CON) or bupivacaine 0.5% epidural infusion (EPI) at 15 µl/h for 2 h on day 1 and day 3. Mean arterial blood pressure, heart rate, respiration rate, arterial PCO₂, and motor score were recorded at baseline and after 30, 60, 90, and 120 min. Skin temperature was measured at front paws, high-thoracic, mid-thoracic, and low-thoracic, hind paws, and the proximal and distal tail. Changes in sympathetic activity were assessed by skin temperature changes from baseline (T). In the EPI group, hemodynamics and respiration remained unchanged and only mild motor deficits occurred. T in thoracic segments was higher in the EPI than in the CON group (P < 0.001 at all times at high-thoracic, mid-thoracic, and low-thoracic segments). Skin temperature decreased in the distal tail in the EPI group, e.g., after 90 min T = –0.86 ± 0.25°C (EPI) versus 0.4 ± 0.12°C (CON) (P < 0.05 at 60, 90, and 120 min). T on day 3 was comparable to day 1. TEA induced stable segmental sympathetic block without cardiorespiratory and motor side effects in awake rats. This new technique may be applied in prolonged models of critical illness.

IMPLICATIONS: Continuous thoracic epidural anesthesia (TEA) was applied in awake rats. Sympathetic block was evaluated by changes in skin temperature. TEA induced segmental sympathetic block without cardiorespiratory side effects. This new technique may be applicable in research evaluating TEA in prolonged models of critical illness.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999