JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Mannion, S. Articles by Shorten, G. D. Search for Related Content PubMed PubMed Citation Articles by Mannion, S. Articles by Shorten, G. D. Related Collections Regional Anesthesia Pharmacology

---

REGIONAL ANESTHESIA

Intravenous but Not Perineural Clonidine Prolongs Postoperative Analgesia After Psoas Compartment Block with 0.5% Levobupivacaine for Hip Fracture Surgery

Department of Anaesthesia and Intensive Care, Cork University Hospital, Cork, Ireland

Address correspondence to Stephen Mannion, MRCPI, FCARCSI, Department of Anaesthesia and Intensive Care, Cork University Hospital, Cork, Ireland. Address e-mail to mannionstephen{at}hotmail.com.

We evaluated the systemic and local effects of clonidine as an analgesic adjunct to psoas compartment block (PCB) with levobupivacaine. In a randomized, prospective, double-blind trial, 36 patients requiring hip fracture surgery received PCB and general anesthesia. Patients were randomized into three groups. Each patient received PCB with 0.4 mL/kg of levobupivacaine 0.5%. The control group (group L) received IV saline, the systemic clonidine group (group IC) received IV clonidine 1 µg/kg, and the peripheral clonidine group (group C) received IV saline and PCB with clonidine 1 µg/kg. The interval from time of completion of block injection to first supplementary analgesic administration was longer in group IC compared with group L (mean ± sd, 13.4 ± 6.1 versus 7.3 ± 3.6 h; P = 0.03). There was no difference between group C and group L (10.3 ± 5.9 versus 7.3 ± 3.6 h; P > 0.05). The groups were similar in terms of 24 h cumulative morphine and acetaminophen consumption. There were no significant differences among groups regarding postoperative adverse effects (bradycardia, hypotension, sedation, and nausea). We conclude that IV but not perineural clonidine (1 µg/kg) prolongs analgesia after PCB without increasing the incidence of adverse effects.

This article has been cited by other articles:

				J. T. YaDeau, V. R. LaSala, L. Paroli, R. L. Kahn, K. M. Jules-Elysee, D. S. Levine, B. L. Wukovits, and J. Y. Lipnitsky Clonidine and Analgesic Duration After Popliteal Fossa Nerve Blockade: Randomized, Double-Blind, Placebo-Controlled Study Anesth. Analg., June 1, 2008; 106(6): 1916 - 1920. [Abstract] [Full Text] [PDF]

				S. Mannion Psoas compartment block CEACCP, October 1, 2007; 7(5): 162 - 166. [Full Text] [PDF]

				J. N. Pratap, R. K. Shankar, and T. Goroszeniuk Co-injection of Clonidine Prolongs the Anesthetic Effect of Lidocaine Skin Infiltration by a Peripheral Action Anesth. Analg., April 1, 2007; 104(4): 982 - 983. [Abstract] [Full Text] [PDF]

				G. Cucchiaro and A. Ganesh The Effects of Clonidine on Postoperative Analgesia After Peripheral Nerve Blockade in Children Anesth. Analg., March 1, 2007; 104(3): 532 - 537. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999