JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Neumann, M. A.
Right arrow Articles by Weiskopf, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Neumann, M. A.
Right arrow Articles by Weiskopf, R. B.
Related Collections
Right arrow Mechanisms
Right arrow Pharmacology

Anesth Analg 2005;100:1003-1006
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000146516.35921.1A

ANESTHETIC PHARMACOLOGY

Solubility of Volatile Anesthetics in Bovine White Matter, Cortical Gray Matter, Thalamus, Hippocampus, and Hypothalamic Area

Mireille A. Neumann, MD, Edmond I Eger, II, MD, and Richard B. Weiskopf, MD

Department of Anesthesia and Perioperative Care, University of California, San Francisco, California

Address correspondence to Edmond I Eger, MD, Box 0464, University of California, San Francisco, San Francisco, CA 94143-0464. Address e-mail to egere{at}anesthesia.ucsf.edu.

Although known for whole brain, values are lacking for solubilities of modern volatile anesthetics in specific brain regions. Some regions should differ from others (e.g., gray matter versus white matter) because they differ in lipid content and because potent inhaled anesthetics are lipophilic. In the present report, we examined this issue in bovine brain, finding that white matter/gas partition coefficients are 1.6 (desflurane) to 2.4 (halothane) times larger than gray matter/gas partition coefficients, with values for isoflurane and sevoflurane lying between these at 1.9. Values for thalamus/gas, hypothalamic area/gas, and hippocampal/gas partition coefficients lie between those for gray and white matter. These data may be useful in defining the parts of the brain involved with return to consciousness during recovery from anesthesia.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
D. J. Sakata, N. A. Gopalakrishnan, J. A. Orr, J. L. White, and D. R. Westenskow
Rapid Recovery from Sevoflurane and Desflurane with Hypercapnia and Hyperventilation
Anesth. Analg., July 1, 2007; 105(1): 79 - 82.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2005 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.