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ANESTHETIC PHARMACOLOGY

A Comparative Evaluation of Inhaled Halothane, Isoflurane, and Sevoflurane During Acute Normovolemic Hemodilution in Dogs

Denise Tabacchi Fantoni, DVM, PhD^*, Denise Aya Otsuki, DVM^*, Aline Magalhães Ambrósio, DVM^*, Eunice Yuriko Tamura^*, and José Otávio Costa Auler, Jr, MD, PhD

*Department of Surgery, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil; and Department of Anesthesiology, School of Medicine, University of São Paulo, São Paulo, Brazil

Address correspondence and reprint requests to Denise Tabacchi Fantoni, DVM, PhD, Department of Surgery, School of Veterinary Medicine, University of São Paulo, Rua Professor Dr. Orlando Marques de Paiva 87, CEP 05508-900, São Paulo, Brazil. Address e-mail to dfantoni{at}fmvz.usp.br.

The hemodynamic response to acute normovolemic hemodilution (ANH) can be affected by the anesthetics used. We randomized 18 mongrel dogs to undergo ANH with 3 different inhaled anesthetics: halothane, isoflurane, or sevoflurane. Hemodynamics, oxygen transport, and gastric pH were measured before blood withdrawal, at the end of hemodilution, and 30 and 60 min after the end of hemodilution. The baseline measurements of all hemodynamic variables were similar among groups, with the exception of heart rate, which was more rapid in the sevoflurane group. Thirty minutes after hemodilution, the cardiac index increased 88%, 86%, and 157% in the halothane, isoflurane, and sevoflurane groups, respectively, whereas arterial-venous oxygen differences and oxygen consumption were larger in the halothane group compared with the isoflurane and sevoflurane groups. Gastric pH obtained by tonometry did not change and was not different among groups. Because the hemodynamic response to ANH was not blunted, all three anesthetics may be safely used for the maintenance of anesthesia.

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