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Anesth Analg 2005;100:1122-1128
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000148128.78529.6B

CRITICAL CARE AND TRAUMA

Perfluorohexane Vapor Has Only Minor Effects on Spatial Pulmonary Blood Flow Distribution in Isolated Rabbit Lungs

Matthias Hübler, MD, DEAA, Axel R. Heller, MD, PhD, DEAA, Jörg U. Bleyl, MD, PhD, Marcelo Gama de Abreu, MD, PhD, Tobias Kroll, Thomas Rössel, MD, and Thea Koch, MD, PhD

From the Department of Anesthesiology and Intensive Care Medicine, Technical University Dresden, Germany

Address correspondence and reprint requests to Matthias Hübler, MD, DEAA, Department of Anesthesiology and Intensive Care Medicine, Carl Gustav Carus University Hospital, Fetscherstr. 74, 01307 Dresden, Germany. Address e-mail to matthias.huebler{at}mailbox.tu-dresden.de.

We tested the hypothesis that administration of perfluorohexane (PFH) vapor does not significantly affect the relative pulmonary blood flow (Qrel) distribution in isolated rabbit lungs. Fourteen isolated rabbit lungs were perfused with a Krebs-Henseleit buffer solution (flow 150 mL/min). Pulmonary afterload was set to 3 mm Hg. The lungs were ventilated with 4% CO2 in room air using a small animal ventilator (respiratory rate, 30 breaths/min; tidal volume, 12 mL/kg body weight; positive end-expiratory pressure, 2 cm H2O). After a steady-state period, 18 vol. % of PFH vapor was administered to 9 lungs for 30 min. In a second set of experiments five lungs served as controls. Change in Qrel distribution was assessed using fluorescent-labeled microspheres. The unpaired Student's t-test was used to compare variables between groups. The paired Student's t-test, the one-sample Student's t-test, the Anderson-Hauck test of equivalence, and Pearson correlation were used to analyze changes within groups. The mean correlation coefficients of Qrel were 0.564 ± 0.182 for the PFH group and 0.502 ± 0.295 for the control group, respectively. No significant changes in Qrel distribution over time and between groups were found. However, in the PFH group a tendency towards redistribution of Qrel to more ventral lung areas was noted. Our results suggest that PFH vapor has no significant effects on redistribution of Qrel in isolated rabbit lungs.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2005 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.