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Anesth Analg 2005;100:987-990
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000147790.76114.3A

ANESTHETIC PHARMACOLOGY

Preventing the Withdrawal Response Associated with Rocuronium Injection: A Comparison of Fentanyl with Lidocaine

Norezalee Ahmad, MBChB, MMed, Choy Yin Choy, MBChB, MMed, FANZCA, Esa Ab Aris, MD, MMed, and Subrahmanyam Balan, MBBS, MMed

Hospital Sultanah Aminah, Johor Bahru, Malaysia; Department of Anesthesiology & Intensive Care, Hospital Universiti Kebangsaan Malaysia, Malaysia

Address correspondence and reprint requests to Norezalee Ahmad, MBChB, MMed, Clinical Anesthesiology Specialist, Hospital Sultanah Aminah, Johor Bahru, Malaysia. Address e-mail to dr_ezalee{at}time.net.my.

We compared the efficacy of IV fentanyl with IV lidocaine as pretreatment for the prevention of withdrawal response after rocuronium injection. For this prospective, randomized, placebo-controlled, double-blind study we recruited 90 patients aged between 18 and 65 yr, ASA physical status I or II, who had undergone elective surgery requiring general anesthesia and positive pressure ventilation. Patients were randomly allocated to 1 of 3 groups: group F received 2 mL IV fentanyl 50 µg/mL (100 µg), group L received 2 mL of preservative-free lidocaine 2% (40 mg), and group P (placebo) received 2 mL of normal saline. The incidence of withdrawal response after rocuronium was 57%, 30%, and 7% in the placebo, lidocaine, and fentanyl groups, respectively. We found a significant reduction in incidence of withdrawal response in both the fentanyl and lidocaine groups when compared with the placebo group (P < 0.05), with the fentanyl group being most effective (P < 0.05). In conclusion, both fentanyl and lidocaine are effective clinical treatments to alleviate the withdrawal response associated with rocuronium injection, with fentanyl being more effective.




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J. Y. Kim, J. Y. Kim, Y. B. Kim, and H. J. Kwak
Pretreatment with remifentanil to prevent withdrawal after rocuronium in children
Br. J. Anaesth., January 1, 2007; 98(1): 120 - 123.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.