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Anesth Analg 2005;100:1263-1266
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000149327.23267.6B

CARDIOVASCULAR ANESTHESIA

The Surgical Patient with Brugada Syndrome: A Four-Case Clinical Experience

Luisa G. Santambrogio, MD*, Simonetta Mencherini, MD*, Marinella Fuardo, MD*, Flavia Caramella, MD*, and Antonio Braschi, PhD{dagger}

*Department of Anesthesia and Intensive Care, IRCCS Policlinico San Matteo, Pavia, and {dagger}Department of Anesthesia and Reanimation, University of Pavia, Pavia, Italy

Address correspondence and reprint requests to Luisa G. Santambrogio, MD, Via Donatello 7, 20020 Villa Cortese (MI), Italy. Address e-mail to salamina2003{at}libero.it.

Brugada syndrome is characterized by a distinctive electrocardiographic pattern (right bundle branch block and ST segment elevation in precordial leads) and a high risk of cardiac arrest for malignant dysrhythmia. The genetic basis is a molecular defect of the cardiac sodium channel and the pattern of inheritance is autosomal dominant. Many factors during general anesthesia (medications, bradycardia, temperature changes) could precipitate malignant dysrhythmia in these patients. Because criteria to identify the surgical patient at high risk for developing malignant dysrhythmia are lacking, we can only speculate about the available studies on nonsurgical patients. We describe four patients during general anesthesia and propose intraoperative and postoperative monitoring (the first 36 h).




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.