JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sanders, R. D.
Right arrow Articles by Maze, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sanders, R. D.
Right arrow Articles by Maze, M.
Related Collections
Right arrow Pediatrics
Right arrow Pain
Right arrow Pharmacology

Anesth Analg 2005;100:1295-1302
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000149595.41576.B3

PEDIATRIC ANESTHESIA

Dexmedetomidine Exerts Dose-Dependent Age-Independent Antinociception but Age-Dependent Hypnosis in Fischer Rats

Robert D. Sanders, MBBS, Mariangella Giombini, MD, Daqing Ma, MD, PhD, Yoko Ohashi, MD, Mahmuda Hossain, PhD, Masahiko Fujinaga, MD, PhD, and Mervyn Maze, FRCP, FRCA, FMedSci

Departments of Anaesthetics and Intensive Care and Biological Sciences, Imperial College London

Address correspondence and reprint requests to Mervyn Maze, MB, ChB, FRCP, FRC, Sir Ivan Magill Professor of Anesthetics, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH. Address e-mail to m.maze{at}ic.ac.uk.

Dexmedetomidine (Dex), an {alpha}2-adrenoceptor agonist, is an effective analgesic and sedative drug in adults; however, little information is available about its efficacy in pediatric populations. Some anesthetics exhibit an age-dependent analgesic effect, e.g., nitrous oxide, being relatively ineffective in newborn rats. We investigated the analgesic and hypnotic efficacy of Dex using 6 cohorts of Fischer rats aged 7, 15, 19, 23, and 29 days and adults exposed to either Dex (10 or 50 µg/kg) or saline subcutaneously. Formalin plantar testing was used to mimic inflammatory pain, and its effect was assessed using immunohistochemical (c-Fos staining) and behavioral methods. The hypnotic action of Dex was assessed by loss of righting reflex. Formalin administration produced a typical nociceptive response in each age group; these nociceptive responses were significantly attenuated by Dex 50 µg/kg at all ages (P < 0.05), whereas Dex 10 µg/kg had little effect. Neonatal rats showed the greatest hypnotic sensitivity to Dex (P < 0.05).




This article has been cited by other articles:


Home page
 Br J AnaesthHome page
R. D. Sanders, D. Ma, P. Brooks, and M. Maze
Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity
Br. J. Anaesth., November 1, 2008; 101(5): 597 - 609.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
S. M. Walker
Pain in children: recent advances and ongoing challenges
Br. J. Anaesth., July 1, 2008; 101(1): 101 - 110.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.