JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Beaussier, M. Articles by Lienhart, A. Search for Related Content PubMed PubMed Citation Articles by Beaussier, M. Articles by Lienhart, A. Related Collections Pain Pharmacology Ambulatory

---

AMBULATORY ANESTHESIA

A Randomized, Double-Blind Comparison Between Parecoxib Sodium and Propacetamol for Parenteral Postoperative Analgesia After Inguinal Hernia Repair in Adult Patients

M. Beaussier, MD^*, H. Weickmans, MD^*, C. Paugam, MD^*, S. Lavazais, MD, J. P. Baechle, MD, P. Goater, MD, A. Buffin, MD^||, J. F. Loriferne, MD^¶, J. F. Perier, MD^#, J. P. Didelot, MD^**, A. Mosbah, MD, R. Said, MD, and A. Lienhart, MD, PhD^*

*CHU St. Antoine, Paris, France; CHU Poitiers, France; Clinique de la Sauvegarde, Lyon, France; HIA Val de Grâce, Paris, France; ||CHU Annecy, France; ¶Hôpital Ste Camille, Bry sur Marne, France; #CHU Tenon, Paris, France; **CHU Brabois, Vandoeuvre, les Nancy, France; and CHU Sahloul, Sousse, Tunisie

Address correspondence and reprint requests to M. Beaussier, MD, Département d’Anesthésie Réanimation, Hôpital St-Antoine, 184 rue du Fbg St-Antoine, 75012 Paris, France. Address e-mail to marc.beaussier{at}sat.ap-hop-paris.fr.

The newly injectable cyclooxygenase-2 selective nonsteroidal antiinflammatory drug, parecoxib, has never been compared with propacetamol, a parenteral formulation of acetaminophen. In this prospective, randomized, double-blind, double-dummy study, we randomly assigned 182 patients scheduled for initial inguinal hernia repair under general anesthesia to receive a single injection of 40 mg parecoxib or 2 injections of 2 g propacetamol within the first 12 h after surgery. The study variables were morphine consumption, pain at rest and while coughing, and patient satisfaction throughout the first 12 h postoperatively. For statistical analysis, we used the Student’s t-test, ², and covariance analysis. Total morphine consumption did not differ between the two groups. Pain was less intense in the parecoxib group at rest (P = 0.035) but did not differ for pain while coughing. The incidence of side effects was similar. Significantly more patients in the parecoxib group rated their pain management as good or excellent (87% versus 70% in the propacetamol group, P = 0.001). Within the first 12 h after inguinal hernia repair in adult patients, a single injection of parecoxib 40 mg compares favorably with 2 injections of propacetamol 2 g.

This article has been cited by other articles:

				G. Riest, J. Peters, M. Weiss, S. Dreyer, P. D. Klassen, B. Stegen, A. Bello, and M. Eikermann Preventive effects of perioperative parecoxib on post-discectomy pain Br. J. Anaesth., February 1, 2008; 100(2): 256 - 262. [Abstract] [Full Text] [PDF]

				J. A. Alhashemi, Q. A. Alotaibi, M. S. Mashaat, T. M. Kaid, R. H. Mujallid, and A. M. Kaki Intravenous acetaminophen vs oral ibuprofen in combination with morphine PCIA after Cesarean delivery: [L'acetaminophene intraveineux vs l'ibuprofene par voie orale comme adjuvant de la morphine AICP apres une cesarienne] Can J Anesth, December 1, 2006; 53(12): 1200 - 1206. [Abstract] [Full Text] [PDF]

				P. F. White Changing Role of COX-2 Inhibitors in the Perioperative Period: Is Parecoxib Really the Answer? Anesth. Analg., May 1, 2005; 100(5): 1306 - 1308. [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999