JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Uskova, A. A.
Right arrow Articles by Brandom, B. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Uskova, A. A.
Right arrow Articles by Brandom, B. W.
Related Collections
Right arrow Pharmacology

Anesth Analg 2005;100:1357-1360
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000148692.50116.6A

ANESTHETIC PHARMACOLOGY

Desflurane, Malignant Hyperthermia, and Release of Compartment Syndrome

Anna A. Uskova, MD, Bryan P. Matusic, DO, and Barbara W. Brandom, MD

Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Address correspondence and reprint requests to Anna A. Uskova, MD, Department of Anesthesiology, Kaufmann Building, Suit 910, 3471 Fifth Ave., Pittsburgh, PA. Address e-mail to uskoaa{at}anes.upmc.edu.

We describe a case of suspected malignant hyperthermia in a healthy 20-yr-old man. The patient underwent urgent release of upper extremity compartment syndrome as a result of traumatic vascular injury. After 3 h of general anesthesia with desflurane, he developed a hypermetabolic state (hypercarbia, hyperthermia, hyperkalemia, and metabolic acidosis), consistent with the diagnosis of malignant hyperthermia. Cardiovascular instability coincided with reperfusion of the injured extremity. Treatment with dantrolene and supporting measures restored cardiovascular stability. Three days later he underwent a successful second surgery under regional block with total IV anesthesia.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2005 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.