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Anesth Analg 2005;100:1468-1469
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000151717.74547.23

NEUROSURGICAL ANESTHESIA

Severe Seizures During Propofol Induction in a Patient with Syringomyelia Receiving Baclofen

Sethuraman Manikandan, MD, PDCC, Prabhat K. Sinha, MD, PDCC, Praveen K. Neema, MD, PDCC, and Ramesh C. Rathod, DA, MD

Department of Anesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala

Address correspondence and reprint requests to S. Manikandan, MD, Assistant Professor, Department of Anesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695011, Kerala, India. Address e-mail to kanmanis{at}sctimst.ac.in.

We report the occurrence of recurrent severe generalized seizures during induction of anesthesia with propofol in a patient with syringomyelia receiving baclofen for flexor spasms undergoing neurosurgery. We discuss the possible epileptogenic interaction between baclofen and propofol in our patient.




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L. J. Voss, J. W. Sleigh, J. P. M. Barnard, and H. E. Kirsch
The Howling Cortex: Seizures and General Anesthetic Drugs
Anesth. Analg., November 1, 2008; 107(5): 1689 - 1703.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2005 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.