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Anesth Analg 2005;100:1693-1695
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000151718.58709.0B

ANESTHETIC PHARMACOLOGY

The Effects of Intravenous Lidocaine on Pain During Injection of Medium- and Long-Chain Triglyceride Propofol Emulsions

Woon Si Yew, MBBS, MMed, Shin Yuet Chong, MBBS, MMed, Kian Hian Tan, MBBS, FANZCA, and Meng Huat Goh, MBBS, MMed, FANZCA

Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Singapore

Address correspondence and reprint requests to Woon Si Yew, Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Outram Road, Singapore 169608. Address e-mail to woonsi{at}doctors.org.uk or ganyws{at}sgh.com.sg.

Propofol formulated in medium- and long-chain tri-glycerides (MCT/LCT) is thought to cause less pain on injection. In this study we sought to determine if adding lidocaine to propofol-MCT/LCT is more effect-ive in decreasing pain compared with propofol-MCT/LCT alone or conventional propofol-lidocaine mixtures. Seventy-five patients were randomized into three groups. Group A received conventional propofol-lidocaine mixtures with 20 mg lidocaine, group B received propofol-MCT/LCT with saline, and group C received propofol-MCT/LCT with 20 mg lidocaine. The incidence of pain was 24% in groups A and B and 4% in group C. The number needed to treat to prevent pain was 5. We conclude that propofol-MCT/LCT-lidocaine mixtures significantly reduce pain.




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A. Rochette, A. F. Hocquet, C. Dadure, D. Boufroukh, O. Raux, J. F. Lubrano, S. Bringuier, and X. Capdevila
Avoiding propofol injection pain in children: a prospective, randomized, double-blinded, placebo-controlled study
Br. J. Anaesth., September 1, 2008; 101(3): 390 - 394.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.