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Anesth Analg 2005;101:149-150
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000153497.60047.80

ANESTHETIC PHARMACOLOGY

Severe Anaphylactic Shock with Methylene Blue Instillation

Pascale Dewachter, MD, PhD, Claudie Mouton-Faivre, MD, Philippe Tréchot, PharmD, PhD, Jean-Claude Lleu, MD, and Paul Michel Mertes, MD, PhD

Service d’anesthésie-réanimation chirurgicale, Hôpital Central CHU, Nancy, France

Address correspondence and reprint requests to Pascale Dewachter, MD, PhD, Service d’anesthésie-réanimation chirurgicale Hôpital Central CHU 29 Avenue du Maréchal de Lattre de Tassigny 54035 Nancy France. Address e-mail to pascale.dewachter{at}wanadoo.fr.

We report a documented severe immunoglobulin E-mediated hypersensitivity reaction associated with use of 1% methylene blue for detection of tubal permeability occurring during general anesthesia. Clinical symptoms, biological assessment results, and cutaneous test positivity confirmed an anaphylactic reaction to methylene blue. This case report confirms the need for systematic allergological investigation of all drugs and substances administered during the perioperative period in the event of a hypersensitivity reaction occurring during anesthesia. Anesthesiologists should be aware of the possibility of hypersensitivity reactions involving any drug or substance used during surgery.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.