JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iannoli, E. D.
Right arrow Articles by Shapiro, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iannoli, E. D.
Right arrow Articles by Shapiro, J. R.

Anesth Analg 2005;101:74-76
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000153019.15297.0B

PEDIATRIC ANESTHESIA

Bidirectional Glenn Shunt Surgery Using Lepirudin Anticoagulation in an Infant with Heparin-Induced Thrombocytopenia with Thrombosis

Ellen D. Iannoli, MD, Michael P. Eaton, MD, and Janine R. Shapiro, MD

Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY USA

Address correspondence to Ellen D. Iannoli, M.D., 601 Elmwood Avenue Box 604, Rochester, NY 14642. Address e-mail to Ellen_iannoli{at}urmc.rochester.edu.

There are few reports of the management of pediatric patients with heparin-induced thrombocytopenia (HIT) requiring cardiac surgery using currently available anticoagulants. We report a case of an infant with HIT requiring a bidirectional Glenn shunt who was successfully managed using lepirudin (r-hirudin, Refludan; Aventis, Bridgewater, NJ). Dosing and monitoring of anticoagulation were difficult, and we suggest caution in the use of lepirudin for cardiac surgery unless reliable monitoring of the degree of anticoagulation becomes available.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.