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Anesth Analg 2005;101:365-370
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000159379.54705.84

AMBULATORY ANESTHESIA

Remifentanil as a Single Drug for Extracorporeal Shock Wave Lithotripsy: A Comparison of Infusion Doses in Terms of Analgesic Potency and Side Effects

Hector J. Medina, MD, Eilish M. Galvin, MB, FCARCSI, Maaike Dirckx, MD, Preveen Banwarie, MSc, Johannes F. H. Ubben, MSc, Freek J. Zijlstra, PhD, Jan Klein, MD, PhD, and Serge J. C. Verbrugge, MD, PhD

Department of Anesthesiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Address correspondence and reprint requests to Eilish Galvin, MB, FCARCSI, Department of Anesthesiology, Erasmus University Medical Center, P.O. Box 2040, 3015 GD Rotterdam, The Netherlands. Address e-mail to eilishgalvin{at}hotmail.com.

This randomized, double-blind study was designed to evaluate analgesic effectiveness and side effects of two remifentanil infusion rates in patients undergoing extracorporeal shock wave lithotripsy (ESWL) for renal stones. We included 200 patients who were administered remifentanil either 0.05 µg · kg–1 · min–1 (n = 100) or 0.1 µg · kg–1 · min–1 (n = 100) plus demand bolus of 10 µg of remifentanil via a patient-controlled analgesia (PCA) device. No other sedating drugs were given. The frequencies of PCA demands and deliveries were recorded. Arterial blood pressure, oxygen saturation, and respiratory rate were recorded throughout the procedure; postoperative nausea and vomiting (PONV), dizziness, itching, agitation, and respiratory depression were measured posttreatment. Visual analog scale (VAS) scores were taken preoperatively, directly postoperatively, and 30 min after finishing the procedure. There were no statistically significant differences in the frequency of PCA demands and delivered boluses or among perioperative VAS scores. The extent of PONV and frequency of dizziness and itching immediately after and dizziness 30 min after the end of treatment were significantly reduced in the smaller dose group. We conclude that a remifentanil regimen of 0.05 µg · kg–1 · min–1 plus 10 µg demands is superior to 0.1 µg · kg–1 · min–1 plus demands, as there was no difference in the VAS scores recorded between groups and it has a less frequent incidence of side effects in patients receiving ESWL.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.