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ANESTHETIC PHARMACOLOGY

The Effect of Different Isoflurane-Fentanyl Dose Combinations on Early Recovery from Anesthesia and Postoperative Adverse Effects

Departamento de Anestesiología, Escuela de Medicina, Pontificia Universidad Católica de Chile. Santiago, Chile

Address correspondence to Hernán R. Muñoz, MD, MSc, Departmento de Anestesiología, Hospital Clínico U.C., Marcoleta 367, Santiago, Chile, PO Box: 114-D. Address e-mail to hmunoz{at}med.puc.cl.

We evaluated the effect of different combinations of fentanyl-isoflurane on early recovery from anesthesia in 80 adult patients undergoing laparoscopic cholecystectomy. Anesthesia was induced with fentanyl 2 µg/kg and thiopental 5 mg/kg. Nitrous oxide was not used and patients were randomly assigned to one of four groups: Group 1 (n = 20) received 0.6% end-tidal isoflurane plus fentanyl, Group 2 (n = 20) received 1.2% end-tidal isoflurane plus fentanyl, Group 3 (n = 20) received 1.8% end-tidal isoflurane plus fentanyl, and Group 4 (n = 20) received only isoflurane. In Groups 1, 2 and 3 isoflurane concentration was kept constant and fentanyl was given as necessary to maintain the mean arterial blood pressure within ± 10% of the minimum mean arterial blood pressure measured in the ward. In Group 4, isoflurane concentration was adjusted to maintain mean arterial blood pressure as above. At the end of skin closure isoflurane was discontinued and the time to spontaneous breathing (TSB), time to extubation (TE) and time to eye opening (TEO) were recorded. In the postanesthesia care unit, the degree of sedation, respiratory rate, Spo₂, emesis, pain, and morphine consumption were evaluated every 15 min for 1 h, and thereafter every 30 min until discharge. Fentanyl requirements were 8.3 ± 4.5 µg/kg (mean ± sd) in Group 1, 3.8 ± 1.3 µg/kg in Group 2, and 3.0 ± 0.7 µg/kg in Group 3 (P < 0.001), whereas in Group 4 the mean end-tidal concentration of isoflurane was 2.0% ± 0.4%. Although the mean TSB was <5.5 min in all groups, TE increased from 7.3 ± 5.1 min in Group 1 to 20.6 ± 10.7 min in Group 4 (P < 0.001), and TEO increased from 7.4 ± 5.1 min in Group 1 to 25.8 ± 9.4 min in Group 4 (P < 0.001). There were no differences among the groups in any of the variables measured in the postanesthesia care unit. This study shows that the combination of a small concentration of isoflurane and a relatively larger dose of fentanyl results in a faster recovery from anesthesia than the inverse combination of doses.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999