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Anesth Analg 2005;101:419-422
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000154198.41162.FA

ANESTHETIC PHARMACOLOGY

The Influence of Desflurane on QTc Interval

Radoslaw Owczuk, MD*, Magdalena A. Wujtewicz, MD*, Wioletta Sawicka, MD*, Jerzy Lasek, MD, PhD{dagger}, and Maria Wujtewicz, MD, PhD*

Departments of *Anaesthesiology and Intensive Therapy, and {dagger}Trauma Surgery, Medical University of Gdansk, Gdansk, Poland

Address correspondence and reprint requests to Radoslaw Owczuk, MD, Department of Anaesthesiology and Intensive Therapy, Medical University of Gdansk, Debinki 7 str., 80-211 Gdansk, Poland. Address e-mail to r.owczuk{at}amg.gda.pl.

Volatile anesthetics may prolong the QTc interval and this may result in grave cardiac arrhythmias. We assessed the effect of desflurane on the QTc interval in 40 ASA physical status I or II patients. Volatile anesthetic induction with desflurane was performed, and after obtaining adequate level of anesthesia, QTc interval, heart rate, and noninvasive arterial blood pressure were measured. Prolongation of the QTc interval was observed within the first minute of anesthesia. There were no differences in QTc interval changes between sexes at any time. We conclude that desflurane prolongs the QTc interval, but that there are no differences between genders in sensitivity to this action.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2005 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.