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Anesth Analg 2005;101:641-644
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000157566.41739.2C

PEDIATRIC ANESTHESIA

Analysis of the Bispectral Index During Natural Sleep in Children

Franca Benini, MD, Manuela Trapanotto, MD, Stefano Sartori, MD, Anna Capretta, MD, Daniela Gobber, MD, Clementina Boniver, MD, and Franco Zacchello, PhD, MD

Department of Pediatrics, University of Padova, Padova, Italy

Address correspondence and reprint requests to Franca Benini, Department of Pediatrics, University of Padova, Padova, Italy. Address e-mail to benini{at}pediatria.unipd.it.

The Bispectral Index (BIS) is a system used to measure sedation levels. Some investigators recently analyzed changes in the BIS during natural sleep in adults and found that the BIS diminished considerably as sleep became deeper. No such studies have been undertaken to investigate changes in the BIS in sleeping children. The aim of this work was to assess the trend of the BIS in the various stages of sleep in a group of children, performing a descriptive analysis on a limited number of cases. We evaluated 15 children with negative clinical findings and a normal electroencephalogram (EEG) as part of their follow-up for prior episodes of epilepsy, recording the BIS and EEG in a waking state, in the various stages of sleep and on reawaking. For each stage, the mean value, the standard deviation, and the range of BIS values were calculated. The results showed that the BIS decreased progressively as sleep became deeper. The correlation between the stage of sleep and the BIS was significant. On reawaking, a slow increase was apparent in the BIS.




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A. Lamas, J. Lopez-Herce, L. Sancho, S. Mencia, A. Carrillo, M. J. Santiago, and V. Martinez
Bispectral Index and Middle Latency Auditory Evoked Potentials in Children Younger Than Two-Years-Old
Anesth. Analg., February 1, 2008; 106(2): 426 - 432.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.