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Anesth Analg 2005;101:661-665
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ane.0000167636.94707.d3

AMBULATORY ANESTHESIA

The Incidence of Transient Neurologic Symptoms After Spinal Anesthesia with Mepivacaine

Jacques T. YaDeau, MD, PhD, Gregory A. Liguori, MD, and Victor M. Zayas, MD

Anesthesiology Department, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York

Address correspondence to J. T. YaDeau, Department of Anesthesiology, Hospital for Special Surgery, 535 East 70th St., New York, NY 10021. Address e-mail to yadeauj{at}hss.edu.

We prospectively evaluated 1273 patients who received spinal (or combined spinal-epidural [CSE]) anesthesia with 1.5% mepivacaine (plain, no glucose) for ambulatory surgery. We hypothesized that analysis of a large series of patients would confirm previous findings that isobaric 1.5% mepivacaine is not frequently associated with transient neurologic symptoms (TNS). Patients were contacted twice after the anesthetic, at days 1–4 and days 6–9. One-thousand-two-hundred-ten patients were successfully contacted postoperatively (95% follow-up rate). None of the patients had permanent neurologic sequelae from the anesthetic. None of the 372 CSE anesthetics was inadequate for surgery. Fourteen of 838 (1.7%) of the spinal anesthetics were inadequate. TNS, defined as the new onset of back pain that radiated bilaterally to buttocks or distally, occurred in 78 patients (6.4%; 95% confidence intervals 5.1%–8%). The mean age of patients who developed TNS (48 ± 14 yr) was older than that of patients without TNS (41 ± 16 yr) (P < 0.001). TNS was not influenced by gender or intraoperative position. The frequent success rate and infrequent rates of complications such as TNS and postdural puncture headache suggest that spinal anesthesia with mepivacaine is likely to be a safe and effective anesthetic for ambulatory patients.




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R. Perez-Castro, S. Patel, Z. V. Garavito-Aguilar, A. Rosenberg, E. Recio-Pinto, J. Zhang, T. J. J. Blanck, and F. Xu
Cytotoxicity of Local Anesthetics in Human Neuronal Cells
Anesth. Analg., March 1, 2009; 108(3): 997 - 1007.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.