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ANESTHETIC PHARMACOLOGY

Cumulative and Bolus In Vitro Contracture Testing with 4-Chloro-3-Ethylphenol in Malignant Hyperthermia Positive and Negative Human Skeletal Muscles

Mark Ulrich Gerbershagen, MD^*, Marko Fiege, MD^*, Ralf Weisshorn, MD, Kerstin Kolodzie, MD, Jochen Schulte am Esch, MD, and Frank Wappler, MD^*

*Department of Anesthesiology, Hospital Köln-Merheim, University Witten/Herdecke, Cologne, Germany; Department of Anesthesiology, University Hospital Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany

Address correspondence and reprint requests to Mark Ulrich Gerbershagen, MD, Department of Anesthesiology, Hospital Köln-Merheim, University Witten/Herdecke, Cologne, Germany. Address e-mail to gerbershagen{at}uke.uni-hamburg.de.

In this study we evaluated the in vitro effects of 4-chloro-3-ethylphenol (CEP) using cumulative (12.5–200 µmol/L) or bolus (75 and 100 µmol/L) administrations, on muscle specimens from malignant hyperthermia (MH) susceptible and MH nonsusceptible patients, respectively. In the cumulative CEP in vitro contracture test, contractures were significantly greater in the MH susceptible compared with the MH nonsusceptible muscles in all concentrations between 25 and 100 µmol/L. There was no overlap between the diagnostic groups at 75 µmol/L of CEP, so this test appears to be feasible for diagnosis of MH susceptibility. The two bolus tests are not diagnostically useful, as overlaps between the diagnostic groups were observed.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999