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Anesth Analg 2005;101:722-725
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000156951.83242.8D

ANESTHETIC PHARMACOLOGY

Subanesthetic Ketamine Does Not Affect 11C-Flumazenil Binding in Humans

Elina Salmi, MD, Jaakko W. Långsjö, MD, Sargo Aalto, MSc, Kjell Någren, PhD, Liisa Metsähonkala, MD, Kaike K. Kaisti, MD, Esa R. Korpi, MD, Jarmo Hietala, MD, and Harry Scheinin, MD

Turku PET Centre, Centre for Cognitive Neuroscience, and the Department of Pharmacology and Clinical Pharmacology, University of Turku, and the Departments of Anesthesiology and Intensive Care, Child Neurology, and Psychiatry, Turku University Hospital, Turku, Finland; Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland

Address correspondence to Elina Salmi, MD, Turku PET Centre, PO Box 52, FIN-20521 Turku, Finland. Address e-mail to anelsa{at}utu.fi.

Positron emission tomography (PET) studies suggest that propofol and inhaled anesthetics increase 11C-flumazenil binding in the living human brain, thus supporting the involvement of {gamma}-aminobutyric acid type A (GABAA) receptors in the mechanism of action of these drugs. Ketamine produces its anesthetic effects primarily by N-methyl-d-aspartate receptor antagonism, but it may also have GABAA receptor agonistic properties. By using PET, we studied the cerebral 11C-flumazenil binding in 10 healthy subjects before and during a subanesthetic racemic ketamine infusion reaching a serum concentration of 350 ± 42 ng/mL. Ketamine did not affect 11C-flumazenil binding to GABAA receptor in the brain, indicating that this mechanism is of minor importance in the actions of subanesthetic ketamine.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.