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Anesth Analg 2005;101:753-757
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ane.0000166953.89536.ed

TECHNOLOGY, COMPUTING, AND SIMULATION

Temperatures in Soda Lime During Degradation of Desflurane, Isoflurane, and Sevoflurane by Desiccated Soda Lime

Michael J. Laster, DVM, and Edmond I. Eger, II, MD

From the Department of Anesthesia and Perioperative Care, University of California, San Francisco, California

Address correspondence to Dr. Edmond I Eger II, Department of Anesthesia, S-455, University of California, San Francisco, California 94143-0464. Address electronic mail to: egere{at}anesthesia.ucsf.edu.

Rarely, fire and patient injury result from the degradation of sevoflurane by desiccated Baralyme®. The present investigation sought to determine whether high temperatures also arose with sevoflurane use in the presence of desiccated soda lime. We desiccated soda lime by directing a 10 L/min flow of oxygen through fresh absorbent. Using 1140 ± 30 g (mean ± sd) of this desiccated absorbent, we filled a single standard absorber canister placed in a standard anesthetic circuit to which we directed a 6 L/min flow of oxygen containing 1.5 minimum alveolar concentration (MAC) desflurane or sevoflurane, or 3.0 MAC desflurane, isoflurane, or sevoflurane (with and without concurrent delivery of 200 mL/min carbon dioxide). In an additional test, 2 canisters (rather than a single canister) containing desiccated absorbent were used and 3.0 MAC sevoflurane was applied. A 3-L reservoir bag served as a surrogate lung, and we ventilated this lung with a minute ventilation of 10 L/min. With desflurane at 1.5 MAC or 3.0 MAC or isoflurane at 3.0 MAC temperatures increased in 20 to 40 min to a peak of 30°C to 45°C and then declined. With 1.5 or 3.0 MAC sevoflurane, temperatures increased to approximately 90°C, after which temperatures declined. Concurrent delivery of carbon dioxide and sevoflurane did not increase the peak temperatures reached. The use of 2 canisters increased the duration but not the peak of increased temperature reached with 3.0 MAC sevoflurane. No fires resulted from degradation of any anesthetic.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.