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Anesth Analg 2005;101:1054-1059
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ane.0000166955.97368.80

ANESTHETIC PHARMACOLOGY

Inhibitory Effects of Intravenous Anesthetics on Mast Cell Function

Takahiro Fujimoto, MD, PhD, Tomoki Nishiyama, MD, PhD, and Kazuo Hanaoka, MD, PhD

Department of Anesthesiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Address correspondence and reprint requests to Takahiro Fujimoto, MD, PhD, zip151-0072 3-33-1-502 Hatayaga, Shibuya ward, Tokyo, Japan. Address e-mail to tfujimot{at}highway.ne.jp.

Mast cells play a protective role in the inflammation and auto-tissue injury. The impairment of mast cell function may influence defense against infection. We investigated the effect of four IV anesthetics (thiopental, midazolam, ketamine, and propofol) on the chemotaxis and exocytosis of mast cells. Canine mast cell chemotaxis was measured by the Boyden's blindwell chamber technique using 100 µg/mL of substance P as a stimulator. We measured mast cell exocytosis by measuring released histamine from mast cells using substance P or gamma-monomeric IgG-mediated crosslinking as a stimulator. Thiopental, midazolam, and propofol exerted a dose-dependent inhibitory effect on mast cell chemotaxis. Ketamine, midazolam, and propofol had a dose-dependent inhibitory effect on mast cell exocytosis. In conclusion, midazolam and propofol inhibited both chemotaxis and exocytosis of mast cells, while thiopental only inhibited chemotaxis, and ketamine only inhibited exocytosis.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2005 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.