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Anesth Analg 2005;101:1063-1064
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ane.0000166791.30963.ef

ANESTHETIC PHARMACOLOGY

The Effect of Anesthesia by Diethyl Ether or Isoflurane on Activity of Cytochrome P450 2E1 and P450 Reductases in Rat Liver

Andrea Y. A. Plate, MSc, Daune L. Crankshaw, PhD, and Daniel D. Gallaher, PhD

Department of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota

Address correspondence and reprint requests to Daniel D. Gallaher, PhD, Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave, St. Paul, MN 55108. Address e-mail to dgallahe{at}che.umn.edu.

In this study we sought to determine whether exposure to the anesthetics diethyl ether and isoflurane influences the activity of hepatic cytochrome P450 2E1 and P450 reductases in the rat. Rats were fed a purified diet for 6 wk before anesthesia with 1 of 3 anesthetics: carbon dioxide, diethyl ether, or isoflurane. Cytochrome P450 2E1 and P450 reductases were measured in liver microsomes. No significant differences in enzyme activities were found among the groups. These results indicate that diethyl ether and isoflurane can be used to kill rats without inducing P450 enzymes.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.