This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Shavit, Y. Articles by Beilin, B. Search for Related Content PubMed PubMed Citation Articles by Shavit, Y. Articles by Beilin, B. Related Collections Postanesthetic Care Unit Anesthetic Techniques Regional Anesthesia Pain Pharmacology

---

PAIN MEDICINE

The Effects of Perioperative Pain Management Techniques on Food Consumption and Body Weight After Laparotomy in Rats

Yehuda Shavit, PhD^*, Gila Fish, MSc^*, Gilly Wolf, PhD C^*, Eduard Mayburd, MD, Ylia Meerson, MD, Raz Yirmiya, PhD^*, and Benzion Beilin, MD

*Department of Psychology, Hebrew University, Jerusalem; and Department of Anesthesiology, Rabin Medical Center, Golda–Hasharon Campus, Petah Tiqva, affiliated with the Sackler School of Medicine, Tel-Aviv University, Israel

Address correspondence and reprint requests to Yehuda Shavit, PhD, Department of Psychology, The Hebrew University, Mount Scopus, Jerusalem 91905, Israel. Address e-mail to Udi.Shavit{at}huji.ac.il.

We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.