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Anesth Analg 2005;101:1112-1116
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ane.0000167771.98680.a7

PAIN MEDICINE

The Effects of Perioperative Pain Management Techniques on Food Consumption and Body Weight After Laparotomy in Rats

Yehuda Shavit, PhD*, Gila Fish, MSc*, Gilly Wolf, PhD C*, Eduard Mayburd, MD{dagger}, Ylia Meerson, MD{dagger}, Raz Yirmiya, PhD*, and Benzion Beilin, MD{dagger}

*Department of Psychology, Hebrew University, Jerusalem; and {dagger}Department of Anesthesiology, Rabin Medical Center, Golda–Hasharon Campus, Petah Tiqva, affiliated with the Sackler School of Medicine, Tel-Aviv University, Israel

Address correspondence and reprint requests to Yehuda Shavit, PhD, Department of Psychology, The Hebrew University, Mount Scopus, Jerusalem 91905, Israel. Address e-mail to Udi.Shavit{at}huji.ac.il.

We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.