| ||||||||||||||
|
|
|||||||||||||



*Department of Psychology, Hebrew University, Jerusalem; and
Department of Anesthesiology, Rabin Medical Center, GoldaHasharon Campus, Petah Tiqva, affiliated with the Sackler School of Medicine, Tel-Aviv University, Israel
Address correspondence and reprint requests to Yehuda Shavit, PhD, Department of Psychology, The Hebrew University, Mount Scopus, Jerusalem 91905, Israel. Address e-mail to Udi.Shavit{at}huji.ac.il.
We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.
|