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Anesth Analg 2005;101:1269-1274
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000181330.57600.FF

CARDIOVASCULAR ANESTHESIA

Myocardial Systolic Function Increases During Positive Pressure Lung Inflation

Michael F. Haney, Göran Johansson, Sören Häggmark, Björn Biber, Michael F. Haney, MD, PhD, Göran Johansson, MS, Sören Häggmark, MS, and Björn Biber, MD, PhD

Anesthesiology and Intensive Care Medicine, Umeå University Hospital, Umeå, Sweden

Address correspondence to Michael Haney, Anesthesiology and Intensive Care Medicine, Umeå University Hospital, 901 85 Umeå, Sweden. Address e-mail to michael.haney{at}anestesi.umu.se.

Lung inflation with positive airway pressure may have rapid and dynamic effects on myocardial contractile function. We designed this study to assess the magnitude and time to onset of myocardial function changes during the initiation of single positive pressure lung inflation at clinically relevant inflation pressures. In 8 anesthetized 40-kg pigs, left ventricular pressures and volumes were measured directly (conductance volumetry). A 15 cm H2O airway pressure plateau with lung inflation (PPLI-15) was performed, and 2 single beats from that sequence, one from resting apnea at zero airway pressure and the second from the point when the lungs were first maximally inflated, were selected for analysis. Systolic function variables for zero airway pressure and PPLI-15 were analyzed. Systolic elastance, derived from bilinear time-varying elastance curves, increased approximately 15% during PPLI-15 from zero airway pressure. This agreed with other systolic function variables that identified an increase in left ventricular contractile function for the lung inflation beat. Serial measurements of myocardial function should be conducted with constant airway pressure and lung inflation conditions.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.