JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Komatsu, R.
Right arrow Articles by Lenhardt, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Komatsu, R.
Right arrow Articles by Lenhardt, R.
Related Collections
Right arrow Postanesthetic Care Unit
Right arrow Complications
Right arrow Pharmacology

Anesth Analg 2005;101:1368-1373
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000180198.13467.DF

ANESTHETIC PHARMACOLOGY

Doxapram Only Slightly Reduces the Shivering Threshold in Healthy Volunteers

Ryu Komatsu, MD*, Papiya Sengupta, MD*, Grigory Cherynak, MD{dagger}, Anupama Wadhwa, MD*{dagger}, Daniel I. Sessler, MD*{dagger}, Jin Liu, MD§, Harrell E. Hurst, PhD§, and Rainer Lenhardt, MD*{dagger}

*Outcomes ResearchTM Institute, University of Louisville; and Departments of {dagger}Anesthesiology & Perioperative Medicine, and §Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky

Address correspondence and reprint requests to Daniel I. Sessler, MD, Outcomes Research Institute, 501 East Broadway, Suite 210, Louisville, KY 40202. Address e-mail to sessler{at}louisville.edu. On the worldwide web: www.or.org.

We determined the effects of doxapram on the major autonomic thermoregulatory responses in humans. Nine healthy volunteers were studied on 2 days: control and doxapram (IV infusion to a plasma concentration of 2.4 ± 0.8, 2.5 ± 0.9, and 2.6 ± 1.1 µg/mL at the sweating, vasoconstriction, and shivering thresholds, respectively). Each day, skin and core temperatures were increased to provoke sweating, then reduced to elicit peripheral vasoconstriction and shivering. We determined the sweating, vasoconstriction, and shivering thresholds with compensation for changes in skin temperature. Data were analyzed with paired t-tests and presented as mean ± sd; P < 0.05 was considered statistically significant. Doxapram did not change the sweating (control: 37.5° ± 0.4°C, doxapram: 37.3° ± 0.4°C; P = 0.290) or the vasoconstriction threshold (36.8° ± 0.7°C versus 36.4° ± 0.5°C; P = 0.110). However, it significantly reduced the shivering threshold from 36.2° ± 0.5°C to 35.7° ± 0.7°C (P = 0.012). No sedation or symptoms of panic were observed on either study day. The observed reduction in the shivering threshold explains the drug’s efficacy for treatment of postoperative shivering; however, a reduction of only 0.5°C is unlikely to markedly facilitate induction of therapeutic hypothermia as a sole drug.




This article has been cited by other articles:


Home page
 Br J AnaesthHome page
R. Komatsu, M. Orhan-Sungur, J. In, T. Podranski, T. Bouillon, R. Lauber, S. Rohrbach, and D. Sessler
Ondansetron does not reduce the shivering threshold in healthy volunteers
Br. J. Anaesth., June 1, 2006; 96(6): 732 - 737.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.