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Anesth Analg 2005;101:1465-1469
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000180193.29655.6A

CRITICAL CARE AND TRAUMA

Slight Increase of Serum S-100B During Porcine Endotoxemic Shock May Indicate Blood-Brain Barrier Damage

Anders Larsson, MD, PhD*, Miklós Lipcsey, MD{dagger}, Jan Sjölin, MD, PhD*, Lars-Olof Hansson, MD, PhD*, and Mats B. Eriksson, MD, PhD{dagger}

Departments of *Medical Sciences and {dagger}Surgical Sciences, Uppsala University Hospital, Sweden

Address correspondence and reprint requests to Anders Larsson, MD, PhD, Department of Medical Sciences, University Hospital S-751 85 Uppsala, Sweden. Address e-mail to anders.larsson{at}akademiska.se.

Septic shock is a condition that affects many organs, but little is known about the effects on the central nervous system. S-100B, an acidic low molecular weight protein, has attracted considerable interest as a marker for brain damage and disintegration of the blood-brain barrier. It is released into the cerebrospinal fluid and blood from brain tissue after brain damage. We studied S-100B in a porcine model of endotoxemic shock that resembles human Gram-negative septic shock. Ten piglets received IV endotoxin, and plasma samples were collected before the endotoxin infusion and each hour (1–6 h) during the endotoxin infusion. S-100B was measured by sandwich enzyme-linked immunosorbent assay. Low levels of plasma S-100B were detected, but there was a significant increase in S-100B during Hours 1–5 in comparison with the 0 values. We determined that endotoxemia causes a very small but significant increase in the levels of the widely used brain damage marker serum S-100B. However, it cannot be excluded that the increase in S-100B could be caused by release from organs other than the brain.




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N. Stocchetti
Brain and Sepsis: Functional Impairment, Structural Damage, and Markers
Anesth. Analg., November 1, 2005; 101(5): 1463 - 1464.
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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.