JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Akyol, A.
Right arrow Articles by Erciyes, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Akyol, A.
Right arrow Articles by Erciyes, N.
Related Collections
Right arrow Critical Care
Right arrow Resuscitation
Right arrow Pharmacology

Anesth Analg 2005;101:1490-1491
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000180195.57760.E9

CRITICAL CARE AND TRAUMA

Delayed Respiratory Depression After Risperidone Overdose

Ahmet Akyol, MD, A. Can Senel, MD, Hülya Ulusoy, MD, Filiz Karip, MD, and Nesrin Erciyes, MD

Department of Anesthesiology and Critical Care, Karadeniz Technical University, Trabzon, Turkey

Address correspondence and reprint requests to Ahmet Akyol, MD, Department of Anesthesiology and Critical Care, Karadeniz Technical University, Faculty of Medicine, 61080 Trabzon, Turkey. Address e-mail to ahmetmelike{at}yahoo.com.

Risperidone is an atypical antipsychotic drug used for the treatment of schizophrenia. Both positive and negative symptoms are prominent with its use. Metabolism occurs mainly in the liver, where risperidone is changed by CUP2D6 to an active metabolite, 9-hydroxyrisperidone. The half-lives of risperidone and its metabolite are 3 and 7 h, respectively. Genetic polymorphism is seen in the 6%–8% of white patients who are considered poor metabolizers. In poor metabolizers, the half-life extends to 20–30 h. We present an unusual case of unanticipated delayed respiratory depression after risperidone overdose.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.