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Anesth Analg 2005;101:1490-1491
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000180195.57760.E9

CRITICAL CARE AND TRAUMA

Delayed Respiratory Depression After Risperidone Overdose

Ahmet Akyol, MD, A. Can Senel, MD, Hülya Ulusoy, MD, Filiz Karip, MD, and Nesrin Erciyes, MD

Department of Anesthesiology and Critical Care, Karadeniz Technical University, Trabzon, Turkey

Address correspondence and reprint requests to Ahmet Akyol, MD, Department of Anesthesiology and Critical Care, Karadeniz Technical University, Faculty of Medicine, 61080 Trabzon, Turkey. Address e-mail to ahmetmelike{at}yahoo.com.

Risperidone is an atypical antipsychotic drug used for the treatment of schizophrenia. Both positive and negative symptoms are prominent with its use. Metabolism occurs mainly in the liver, where risperidone is changed by CUP2D6 to an active metabolite, 9-hydroxyrisperidone. The half-lives of risperidone and its metabolite are 3 and 7 h, respectively. Genetic polymorphism is seen in the 6%–8% of white patients who are considered poor metabolizers. In poor metabolizers, the half-life extends to 20–30 h. We present an unusual case of unanticipated delayed respiratory depression after risperidone overdose.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2005 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.