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Anesth Analg 2005;101:1572-1576
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000181834.39483.0B

CARDIOVASCULAR ANESTHESIA

Increasing Heart Size and Age Attenuate Anesthetic Preconditioning in Guinea Pig Isolated Hearts

Matthias L. Riess, MD, PhD, Amadou K. S. Camara, PhD, Samhita S. Rhodes, PhD, Joseph McCormick, BS, Ming T. Jiang, MB, PhD, and David F. Stowe, MD, PhD

Departments of Anesthesiology and Physiology, Cardiovascular Research Center, Medical College of Wisconsin, and the VA Medical Center Research Service, Milwaukee, Wisconsin

Address correspondence and reprint requests to Matthias L. Riess, MD, PhD, Medical College of Wisconsin, M4280, 8701 Watertown Plank Road, Milwaukee, WI 53226. Address e-mail to mriess{at}mcw.edu.

Anesthetic preconditioning (APC) reduces myocardial ischemia/reperfusion injury. Recent investigations have reported that older hearts are not susceptible to APC. We investigated if increasing heart size with age determines the susceptibility to APC in young guinea pigs. Langendorff-prepared guinea pig hearts of different weights (1.1–2.2 g) and ages (2–7 wks) were exposed to 1.3 mM sevoflurane for 15 min followed by 30 min washout (APC; n = 20) before 30 min global ischemia and 120 min reperfusion. Control hearts (n = 20) were not subject to APC. Left ventricular pressure was measured isovolumetrically and infarct size was determined by triphenyltetrazolium staining. Functional data were not different between groups at the beginning of the experiments nor did they correlate with heart weight or age. At 120 min reperfusion, left ventricular pressure, coronary flow, and tissue viability showed significant negative correlations with increasing heart weight and age in APC but not in control hearts; i.e., APC improved function and attenuated infarct size better in smaller/younger hearts than in larger/older hearts. Thus, increasing age and heart size attenuate the susceptibility for APC even in younger guinea pigs. This may have important implications for further basic science research and the possible clinical applicability of APC in humans.




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[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.