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Anesth Analg 2005;101:1584-1589
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000184044.51749.B8

CARDIOVASCULAR ANESTHESIA

Isoflurane Protects Renal Function Against Ischemia and Reperfusion Through Inhibition of Protein Kinases, JNK and ERK

Hideo Hashiguchi, MD, Hiroaki Morooka, MD, Hiroshi Miyoshi, MD, Masanori Matsumoto, MD, Takehiko Koji, MD, and Koji Sumikawa, MD

Department of Anesthesiology, Department of Histology, Nagasaki University School of Medicine, Nagasaki, Japan

Address correspondence and reprint requests to Koji Sumikawa, MD, Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1, Sakamoto, Nagasaki 852–8501, Japan. Address e-mail to cds93710{at}syd.odn.ne.jp.

Isoflurane has a pharmacological preconditioning effect against ischemia in the heart and brain, but whether this also occurs in the kidney is unclear. In this study, we investigated pharmacological preconditioning by isoflurane in the rat kidney. In the isoflurane preconditioning group (1.5% isoflurane for 20 min before renal ischemia) serum creatinine (1.2 ± 0.7 and 1.1 ± 0.2 mg/dL) and blood urea nitrogen (99 ± 29 and 187 ± 31 mg/dL) were significantly smaller at 24 and 48 h after reperfusion than in the nonpreconditioning group (creatinine; 2.4 ± 1.2 and 2.9 ± 0.9 mg/dL, urea; 62 ± 19 and 79 ± 20 mg/dL). We also investigated the intracellular signal transduction involved in isoflurane preconditioning in the kidney. The activities of the stress protein kinases, JNK and ERK but not p38, were significantly less in the kidneys of the preconditioning group than in those of the nonpreconditioning group (P < 0.05). We conclude that isoflurane has a preconditioning effect against renal ischemia/reperfusion injury when administered before ischemia. Inhibition of the protein kinases, JNK and ERK, might be involved in the mechanisms of isoflurane preconditioning.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.