JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Liu, N. Articles by Fischler, M. Search for Related Content PubMed PubMed Citation Articles by Liu, N. Articles by Fischler, M. Related Collections Equipment Monitoring (Non-cardiac) Technology Pharmacology

---

TECHNOLOGY, COMPUTING, AND SIMULATION

The Influence of a Muscle Relaxant Bolus on Bispectral and Datex-Ohmeda Entropy Values During Propofol-Remifentanil Induced Loss of Consciousness

Ngai Liu, MD^*, Thierry Chazot, MD^*, Isabelle Huybrechts, MD, Jean-Dominique Law-Koune, MD^*, Luc Barvais, MD, and Marc Fischler, MD^*

*Department of Anesthesiology, Hôpital Foch, Suresnes, France; Department of Anesthesiology, Hôpital Erasme, ULB, Brussels, Belgium

Address correspondence and reprint requests to Marc Fischler, MD, Service d’Anesthésie Hôpital Foch, 40 rue Worth, 92151 Suresnes, France. Address e-mail to m.fischler{at}hopital-foch.org.

Studies investigating the influence of muscle relaxants on the bispectral index have yielded contradictory results. In our prospective, randomized, double-blind experiments, patients received a fixed target concentration of remifentanil along with a target-controlled infusion of propofol, titrated until loss of consciousness. Two minutes after loss of consciousness, the study group received a bolus injection of atracurium, whereas the control group received a placebo. The following variables were recorded: bispectral index, spectral edge frequency, electromyographic activity, state entropy, and response entropy provided by the Datex-Ohmeda Entropy monitor. Similar values were obtained in both groups at loss of consciousness. Placebo administration induced a decrease in bispectral index (P < 0.002), spectral edge frequency (P < 0.05), electromyographic activ-ity (P < 0.02), state entropy (P < 0.05), and response entropy (P < 0.01) compared with the values measured at loss of consciousness. Atracurium administration induced a decrease in bispectral index (P < 0.0001), spectral edge frequency (P < 0.01), electromyographic activity (P < 0.0001), state entropy (P < 0.0001), and response entropy (P < 0.0001) values. Decreases in bispectral index (P < 0.05), electromyographic activity (P < 0.0001), and response entropy (P < 0.01) were larger after atracurium than placebo injection. In lightly anesthetized patients, myorelaxant administration decreases bispectral index and response entropy, but not state entropy values.

This article has been cited by other articles:

				G. Weil, S. Passot, F. Servin, and V. Billard Does Spectral Entropy Reflect the Response to Intubation or Incision During Propofol-Remifentanil Anesthesia? Anesth. Analg., January 1, 2008; 106(1): 152 - 159. [Abstract] [Full Text] [PDF]

				V. Bonhomme and P. Hans Muscle relaxation and depth of anaesthesia: where is the missing link? Br. J. Anaesth., October 1, 2007; 99(4): 456 - 460. [Full Text] [PDF]

				A. Ekman, E. Stalberg, E. Sundman, L. I. Eriksson, L. Brudin, and R. Sandin The Effect of Neuromuscular Block and Noxious Stimulation on Hypnosis Monitoring During Sevoflurane Anesthesia Anesth. Analg., September 1, 2007; 105(3): 688 - 695. [Abstract] [Full Text] [PDF]

				P.-Y. Lequeux, G. Bejjani, and R. Flament Influence of Cisatracurium on Entropy Values During Propofol-Remifentanil Anesthesia Anesth. Analg., January 1, 2007; 104(1): 228 - 229. [Full Text] [PDF]

				P. Panousis, T. Koch, and A. R. Heller The Effects of Electromyographic Activity on the Bispectral Index During Combined Anesthesia Anesth. Analg., December 1, 2006; 103(6): 1605 - 1605. [Full Text] [PDF]

				M. Renna and C. Gillbe BIS and the Electromyogram Anesth. Analg., October 1, 2006; 103(4): 1049 - 1049. [Full Text] [PDF]

				N. Liu, T. Chazot, and M. Fischler BIS and the Electromyogram Anesth. Analg., October 1, 2006; 103(4): 1049 - 1050. [Full Text] [PDF]

				N. Liu, T. Chazot, and M. Fischler Changes of Bispectral Index After a Bolus Dose of Muscle Relaxant Anesth. Analg., September 1, 2006; 103(3): 777 - 777. [Full Text] [PDF]

				M. T. V. Chan and T. Gin Changes of bispectral index after a bolus dose of muscle relaxant. Anesth. Analg., September 1, 2006; 103(3): 776 - 777. [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999