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Anesth Analg 2005;101:1809-1811
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000184203.52747.7D

CRITICAL CARE AND TRAUMA

The Use of Small-Dose Theophylline for the Treatment of Bradycardia in Patients with Spinal Cord Injury

Sebastian Schulz-Stübner, MD, PhD

Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City

Address correspondence and reprint requests to Sebastian Schulz-Stübner, MD, PhD, University of Iowa Hospitals and Clinics Department of Anesthesia, 6JCP 200 Hawkins Dr., Iowa City, IA 52242. Address e-mail to sebastian-schulz-stubner{at}uiowa.edu.

Small-dose theophylline can be a useful alternative in the treatment of bradycardia in patients with spinal cord injury. In this series of three cases, I describe its successful use for this indication. In one case, initiation of theophylline treatment also increased respiratory drive and minute ventilation. A possible mechanism is that theophylline increases the force of contraction of diaphragmatic muscles because of enhancement of calcium uptake through an adenosine-mediated channel. The antibradycardiac effect is probably mediated through one or more different molecular mechanisms, which seem to be mediated by inhibition of phosphodiesterase 3.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.