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Anesth Analg 2005;101:1873-1876
© 2005 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000184196.60838.8D

GENERAL ARTICLES

The Relationship Between Salivary Biomarkers and State-Trait Anxiety Inventory Score Under Mental Arithmetic Stress: A Pilot Study.

Yuka Noto*, Tetsumi Sato{dagger}, Mihoko Kudo{dagger}, Kiyoshi Kurata{ddagger}, and Kazuyoshi Hirota{dagger}

Department of *Nursing, {dagger}Anesthesiology, and {ddagger}First Department of Physiology, Hirosaki University School of Health Sciences, Japan

Address correspondence and reprint requests to Kazuyoshi Hirota, MD, FRCA, Department of Anesthesiology, Hirosaki University School of Medicine, Hirosaki 036–8563, Japan. Address e-mail to masuika{at}cc.hirosaki-u.ac.jp.

Measurement of stress hormones is a common objective method for assessment of mental stress. However, the stress of blood sampling alone may also increase stress hormone levels. In the present study, we sampled salivary biomarkers from healthy volunteers under noninvasive conditions and determined their efficacy to assess mental stress. Specifically, we examined the relationship between State Anxiety Inventory score (STAI-s) in subjects exposed to arithmetic stress and salivary chromogranin-A, {alpha}-amylase, or cortisol. The STAI-s was significantly correlated to salivary {alpha}-amylase (r = 0.589; P < 0.01) but not to salivary chromogranin-A or cortisol. Therefore, salivary {alpha}-amylase is a useful indicator of psychosocial stress.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2005 by the International Anesthesia Research Society.