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Anesth Analg 2006;102:124-128
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000184829.25310.38

ANESTHETIC PHARMACOLOGY

Actions of Norepinephrine and Isoflurane on Inhibitory Synaptic Transmission in Adult Rat Spinal Cord Substantia Gelatinosa Neurons

Stefan K. Georgiev, MD, Ayako Wakai, MD, PhD, Tatsuro Kohno, MD, PhD, Tomohiro Yamakura, MD, PhD, and Hiroshi Baba, MD, PhD

Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences

Address correspondence and reprint requests to Hiroshi Baba, MD, PhD, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachidori, 951-8510 Niigata, Japan. Address e-mail baba{at}med.niigata-u.ac.jp.

Volatile inhaled anesthetics and nitrous oxide (N2O) are often used together in clinical practice to produce analgesia. Because the analgesic effect of N2O is, at least in part, mediated by norepinephrine (NE) release in the spinal cord, we examined the interaction between isoflurane (ISO) and NE in the adult rat spinal cord with respect to central nociceptive information processing. The effects of clinically relevant concentrations of ISO (1 MAC) and NE (20 µM) on spontaneous inhibitory transmission in substantia gelatinosa (SG) neurons were examined using the blind whole-cell patch-clamp method. ISO prolonged the decay time and increased the total charge transfer of spontaneous inhibitory postsynaptic currents. NE increased the frequency and mean amplitude of inhibitory postsynaptic currents and the charge transfer as well. Coapplication of both drugs led to an additive increase of the charge transfer and frequent temporal summation of inhibitory postsynaptic currents. We conclude that both ISO and NE enhance the inhibitory synaptic transmission in the rat SG neurons and their interaction is additive, suggesting that ISO may add to the analgesic action of N2O at the spinal cord dorsal horn level.




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J. Kim, A. Yao, R. Atherley, E. Carstens, S. L. Jinks, and J. F. Antognini
Neurons in the Ventral Spinal Cord Are More Depressed by Isoflurane, Halothane, and Propofol Than Are Neurons in the Dorsal Spinal Cord
Anesth. Analg., October 1, 2007; 105(4): 1020 - 1026.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.