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ANESTHETIC PHARMACOLOGY

The Analgesic Effect of Tramadol After Intravenous Injection in Healthy Volunteers in Relation to CYP2D6

Thomas P. Enggaard, MD^*, Lars Poulsen, MD^*, Lars Arendt-Nielsen, PhD, Kim Brøsen, MD^*, Joachim Ossig, PhD^||, and Søren H. Sindrup, MD

* Clinical Pharmacology, University of Southern Denmark, Department of Anaesthesiology and Intensive Care, Department of Neurology, Odense University Hospital, Odense, Denmark. Center of Sensory-Motor Interaction Aalborg University, Denmark; ||Department of Pharmacokinetics Grünenthal GmbH, Aachen, Germany

Address correspondence and reprint requests to Thomas P. Enggaard, Clinical Pharmacology, IST, University of Southern Denmark, DK-5000 Odense C, Denmark. Address e-mail to t.enggaard{at}dadlnet.dk.

Tramadol analgesia results from a monoaminergic effect by tramadol itself and an opioid effect of its metabolite (+)-M1 formed by O-demethylation of tramadol by CYP2D6. In this study we sought to determine the impact of (+)-M1 on the analgesic effect of tramadol evaluated by experimental pain models. The effect of an IV injection of 100 mg tramadol on experimental pain was studied 15–90 min after dosing in volunteers, 10 extensive metabolizers with CYP2D6 and 10 poor metabolizers without CYP2D6 in 2 placebo-controlled trials. The pain tests included detection and tolerance threshold to single electrical sural nerve stimulation, pain summation threshold to repetitive electrical sural nerve stimulation (temporal summation), and the cold pressor test. In extensive metabolizers, tramadol reduced discomfort experienced during the cold pressor test (P = 0.002). In poor metabolizers, the pain tolerance thresholds to sural nerve stimulation were increased (P = 0.04). (+)-M1 could be detected in the serum samples from all extensive metabolizers except one, but (+)-M1 was below the limit of determination in all poor metabolizers. The opioid effect of (+)-M1 appears to contribute to the analgesic effect of tramadol, but the monoaminergic effect of tramadol itself seems to create an analgesic effect.

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