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Anesth Analg 2006;102:225-232
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000189554.41095.98

CRITICAL CARE AND TRAUMA

Pretreatment with Simvastatin Reduces Lung Injury Related to Intestinal Ischemia-Reperfusion in Rats

Arash Pirat, MD*, Pinar Zeyneloglu, MD*, Derya Aldemir, MD{dagger}, Muammer Yücel, MD{dagger}, Özlem Özen{ddagger}, Selim Candan, MD*, and Gülnaz Arslan, MD*

Departments of *Anesthesiology, {dagger}Biochemistry, and {ddagger}Pathology, Baskent University Faculty of Medicine, Ankara, Turkey

Address correspondence and reprint requests to Arash Pirat, MD, Baskent Üniversitesi Hastanesi, Anesteziyoloji Anabilim Dali, 10. Sok. No: 45 Bahçelievler, 06490 Ankara, Turkey. Address e-mail to arashp{at}baskent-ank.edu.tr.

In this rat model study we evaluated whether pretreatment with simvastatin affects the severity of acute lung injury caused by intestinal ischemia-reperfusion (I/R). Twenty-four animals were randomly allocated to three equal groups (sham, control, simvastatin). The simvastatin group was pretreated with simvastatin 10 mg · kg–1 · day–1 for 3 days, whereas the other groups received placebo. The simvastatin and control groups underwent 60 min of superior mesenteric artery occlusion and 90 min of reperfusion. Compared with the simvastatin group, the control group exhibited significantly more severe intestinal I/R-induced acute lung injury, as indicated by lower Pao2 and oxygen saturation (P = 0.01 and P = 0.005, respectively) and higher mean values for neutrophil infiltration of the lungs (P = 0.003), total lung histopathologic injury score (P = 0.003), lung wet-to-dry weight ratio (P = 0.009), and lung-tissue malondialdehyde levels (P = 0.016). The control and simvastatin groups had similar serum levels and similar bronchoalveolar lavage fluid levels of cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-{alpha}) and P-selectin at all measurements, except for a significantly higher level of bronchoalveolar lavage fluid P-selectin in the control group (P = 0.006). Pretreatment with simvastatin reduces the severity of acute lung injury induced by intestinal I/R in rats.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.