JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lemmens, H. J. M.
Right arrow Articles by Brodsky, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lemmens, H. J. M.
Right arrow Articles by Brodsky, J. B.

Anesth Analg 2006;102:438-442
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000194876.00551.0e

ANESTHETIC PHARMACOLOGY

The Dose of Succinylcholine in Morbid Obesity

Harry J. M. Lemmens, MD, PhD, and Jay B. Brodsky, MD

Department of Anesthesia, Stanford University School of Medicine, Stanford, California

Address correspondence and reprint requests to Dr. Jay Brodsky, Department of Anesthesia, H3580, Stanford University Medical Center, Stanford, CA 94305. Address e-mail to jbrodsky{at}stanford.edu.

The appropriate dose of succinylcholine (SCH) in morbidly obese patients is unknown. We studied 45 morbidly obese (body mass index >40 kg/m2) adults scheduled for gastric bypass surgery. The response to ulnar nerve stimulation of the adductor pollicis muscle at the wrist was recorded using the TOF-Watch SX® acceleromyograph. In a randomized double-blind fashion, patients were assigned to one of three study groups. In Group I, patients received SCH 1 mg/kg ideal body weight, in Group II 1 mg/kg lean body weight, and in Group III 1 mg/kg total body weight. After SCH administration, endotracheal intubating conditions were scored. The recovery from neuromuscular block was recorded for 20 min. There was no difference in the onset time of maximum neuromuscular blockade among groups, but maximum block was significantly less in Group I. The recovery intervals were significantly shorter in Groups I and II. In one third of the patients in Group I, intubating conditions were rated poor, whereas no patient in Group III had poor intubating conditions. Our study demonstrates that for complete neuromuscular paralysis and predictable laryngoscopy conditions, SCH 1 mg/kg total body weight is recommended.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
H. Gonzalez, V. Minville, K. Delanoue, M. Mazerolles, D. Concina, and O. Fourcade
The Importance of Increased Neck Circumference to Intubation Difficulties in Obese Patients
Anesth. Analg., April 1, 2008; 106(4): 1132 - 1136.
[Abstract] [Full Text] [PDF]

Home page
 JWatch Emergency Med.Home page
Succinylcholine: Dose by Total Body Weight for Obese Patients
Journal Watch Emergency Medicine, February 28, 2006; 2006(228): 3 - 3.
[Full Text]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.