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Anesth Analg 2006;102:495-498
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000189191.71449.48

TECHNOLOGY, COMPUTING, AND SIMULATION

The Auditory Middle Latency Response, Evoked Using Maximum Length Sequences and Chirps, as an Indicator of Adequacy of Anesthesia

Steven L. Bell, BA, MSc, PhD{dagger}, David C. Smith, BMedSci, BM, BS, DM, FRCA*, Robert Allen, BSc, PhD, CEng, FIEE, FIMechE, FIPEM*, and Mark E. Lutman, BSc, MSc, PhD*

*Institute of Sound and Vibration Research, University of Southampton, {dagger}Department of Anaesthetics, Southampton General Hospital, Southampton, United Kingdom

Address correspondence to S. L. Bell, BA, MSc, PhD, Institute of Sound and Vibration Research, University of Southampton, Southampton SO17 1BJ, United Kingdom. Address e-mail to slbi{at}svr.soton.ac.uk.

The auditory evoked potential known as the middle latency response (MLR), evoked with regular click stimulation at around 5 Hz, has been suggested as an indicator of adequacy of anesthesia. The MLR is a very small signal embedded in high levels of background noise, so it can take a long time to acquire. However, using a stimulus paradigm of chirps presented in a maximum length sequence, the acquisition of the MLR can be improved compared to using conventional click stimulation. In this pilot study, we investigated this new technique in a clinical environment. Significant changes in MLR amplitude, but not latency, were measured for six of seven subjects in association with changes in responsiveness to command using the isolated forearm technique. The absence of any latency shift differs from other studies of the MLR during anesthesia and highlights the limited understanding of the relationship between anesthesia and the MLR.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.