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Anesth Analg 2006;102:811-814
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000197690.19075.bd

ANESTHETIC PHARMACOLOGY

Licking and C-Fos Expression in the Dorsal Horn of the Spinal Cord After the Formalin Test

Taeko Fukuda, MD, Kazuhiro Watanabe, MD, Setsuji Hisano, PhD, and Hidenori Toyooka, MD

Department of Anesthesiology, Institute of Clinical Medicine; Tsukuba University Hospital; Laboratory of Neuroendocrinology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, Tsukuba University, Tsukuba-city, Ibaraki, Japan

Address correspondence and reprint requests to Taeko Fukuda, MD, Department of Anesthesiology, Institute of Clinical Medicine; Tsukuba University, Tsukuba-city, Ibaraki 305-8575, Japan. Address e-mail to taekof{at}md.tsukuba.ac.jp.

We investigated whether c-fos expression in the dorsal horn is affected by licking in the formalin test. Thirty adult Sprague-Dawley rats were divided into 5 groups of 6 rats each: a free condition control (Free Cont) group, formalin test under free condition (Free F-test) group, scrub stimulation under free condition (Free Scrub) group, restrained condition control (Restricted Cont) group, and formalin test under restrained condition (Restricted F-test) group. Animals in the three free condition groups and two restricted groups were put in a clear plastic chamber and a restraining chamber, respectively. Ten percent formalin was injected into the left rear paw in the Free and Restricted F-test groups. Animals in the Free Scrub group were scrubbed on the left rear paw with a wet cotton swab. The Free Cont, Restricted Cont, and Free Scrub groups showed little c-fos expression. The number of c-fos positive cells in the ipsilateral surface dorsal horn of the Restricted F-test group was significantly less than that of the Free F-test group (P < 0.05). The results indicated that the licking action increased c-fos expression of the lumbar dorsal horn in the formalin test.




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 Anesth. Analg.Home page
T. Fukuda, S. Hisano, and M. Tanaka
Licking Decreases Phosphorylation of Extracellular Signal-Regulated Kinase in the Dorsal Horn of the Spinal Cord After a Formalin Test
Anesth. Analg., October 1, 2009; 109(4): 1318 - 1322.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.