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PAIN MEDICINE

Intrathecal Catheter Granuloma Associated with Isolated Baclofen Infusion

Paul M. Murphy, MB, MRCPI, FCARCSI^*, Danielle E. Skouvaklis, MD^*, Ryan J.J. Amadeo, MD^*, Craig Haberman, MD^*, David H. Brazier, MD, and Michael J. Cousins, AM, MD, FFPMANZCA^*

*University of Sydney Pain Management and Research Institute and Department of Radiology, Royal North Shore Hospital, St. Leonards, Australia

Address correspondence and reprint requests to Paul M. Murphy, MB, MRCPI, FCARCSI, University of Sydney Pain Management and Research Institute, Department of Radiology, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. Address e-mail to: drpmurphy{at}hotmail.com

Intrathecal (IT) baclofen is an effective management strategy for controlling spasticity in patients unresponsive to maximal oral therapy. We present the case of a 57-yr-old woman who was rendered quadriplegic after a complete spinal cord transection at the C6 level. Her course was complicated by severe spasms, which were uncontrolled despite titrating orally administered baclofen to 80 mg/d. IT baclofen testing was performed with good response, and administration was commenced via an implanted intrathecal pump 6 mo after the injury at an initial dose of 200µg/d. Catheter revision was required 2 wk later as a result of catheter displacement. The initial IT baclofen dose was gradually increased to achieve good control at a level of 400 µg/d. After a period of stability lasting 38 mo, her lower limb spasms dramatically increased in severity and remained poorly controlled despite repeated dose increases. Contrast pumpogram and computed tomography myelogram were performed to exclude a mechanical cause for this apparent increase in baclofen requirement. These investigations revealed neither catheter displacement nor fracture as suspected but, rather, displayed the presence of a catheter tip-associated mass. Catheter tip granuloma has not previously been described in a patient receiving IT baclofen alone. This suggests that although uncommon, the possibility of catheter-associated granuloma must be considered in all patients receiving IT baclofen presenting with altered neurological function or significant increase in drug requirement.

This article has been cited by other articles:

				J. A. Phillips, E. J. Escott, J. J. Moossy, and H. C. Kellermier Imaging Appearance of Intrathecal Catheter Tip Granulomas: Report of Three Cases and Review of the Literature Am. J. Roentgenol., December 1, 2007; 189(6): W375 - W381. [Abstract] [Full Text] [PDF]

				R. J. Coffey and J. W. Allen Not All Intrathecal Catheter Tip MRI Findings Are Inflammatory Masses Anesth. Analg., June 1, 2007; 104(6): 1600 - 1602. [Full Text] [PDF]

				S. N. Narouze and N. A. Mekhail Intrathecal Catheter Granuloma with Baclofen Infusion Anesth. Analg., January 1, 2007; 104(1): 209 - 209. [Full Text] [PDF]

				M. J. Cousins and P. M. Murphy Intrathecal Catheter Granuloma with Baclofen Infusion Anesth. Analg., January 1, 2007; 104(1): 209 - 210. [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999