JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Atkins, J. H.
Right arrow Articles by Johansson, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Atkins, J. H.
Right arrow Articles by Johansson, J. S.
Related Collections
Right arrow Mechanisms
Right arrow Critical Care
Right arrow Economics and Health Care Research

Anesth Analg 2006;102:1207-1216
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000198673.23026.b3

CRITICAL CARE AND TRAUMA

Technologies to Shape the Future: Proteomics Applications in Anesthesiology and Critical Care Medicine

Joshua H. Atkins, MD, PhD*, and Jonas S. Johansson, MD, PhD*{ddagger}

Departments of *Anesthesiology and Critical Care, {dagger}Biochemistry and Biophysics, and {ddagger}the Johnson Research Foundation, University of Pennsylvania, Philadelphia

Address correspondence and reprint requests to Jonas S. Johansson, 319C, John Morgan Building, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104. Address e-mail to JohanssJ{at}uphs.upenn.edu.

Broadly speaking, proteomics is concerned with the simultaneous characterization of the features (for example, the concentration or activity) of the many different proteins that are typically found in biological or clinical specimens. The field is being driven forward both by innovative biotechnology companies and by academicians who are introducing the technology required for the parallel identification of individual proteins. The technology currently relies heavily on two-dimensional gel electrophoresis combined with mass spectrometry, but protein microarray chips are rapidly becoming a reality. Protein biomarkers are increasingly being recognized as crucially important for the study of disease processes, both from diagnostic and prognostic points of view. Proteome level studies will therefore be used increasingly both to identify and follow the course of various pathological conditions. In the specialty of anesthesiology, this technology will allow an improved understanding of the mechanisms of action of many of the drugs that are routinely administered in the operating room and also the effects of these therapeutic drugs on protein expression. In addition, proteomic studies will increasingly be used for both diagnostic and prognostic purposes in the intensive care unit and the chronic pain clinic.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.