This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Martín Cancho, M. F. Articles by Usón-Gargallo, J. Search for Related Content PubMed PubMed Citation Articles by Martín Cancho, M. F. Articles by Usón-Gargallo, J. Related Collections Cardiovascular Monitoring (Cardiac) Monitoring (Non-cardiac) Pharmacology

---

CARDIOVASCULAR ANESTHESIA

The Measurement of Neurovegetative Activity During Anesthesia and Surgery in Swine: An Evaluation of Different Techniques

Minimally Invasive Surgery Centre, Avda/ Universidad s/n, Cáceres, Spain; the Department of Anesthesiology, Medical School, Hospital Universitario de Puerto Real, Cádiz University, Cadiz, Spain

Address correspondence to Dr. Martín Cancho, Minimally Invasive Surgery Centre, Avda/ Universidad s/n, 10071 Cáceres, Spain. Address e-mail to mmartinc{at}ccmi.es.

In this study we evaluated, in 10 sevoflurane-anesthetized pigs undergoing abdominal surgery, different techniques for measuring autonomic nervous system (ANS) activity: ANSiscope^TM index, spectral analysis of heart-rate variability, hemodynamic variables, and plasma catecholamines and cortisol levels. Animals underwent a 120-min anesthesia during which unilateral ovariectomy was performed. Cardiovascular and respiratory responses were monitored. ANSiscope^TM indices (ANSindex^TM sympathetic, ANSindex^TM parasympathetic and balANSindex^TM) were used to monitor ANS activity. Spectral analysis was performed using an autoregressive model with a parametric method. The low frequency (LF) and high frequency (HF) components were used to interpret the power spectral density of short-term electrocardiograms (ECGs). The relationship LF/(LF+HF) reflects sympathetic activity, HF/(LF+HF) indicates parasympathetic activity, and the LF/HF ratio gives the predominance of the system. Plasma concentrations of adrenaline, noradrenaline, and cortisol were determined at different times. Correlation (P < 0.01) was found between the balANSindex^TM and adrenaline levels and between LF/HF ratio and plasma adrenaline concentrations. Moreover, a significant (P < 0.01) correlation was found between the balANSindex^TM and LF/HF ratio. However, no correlation was seen between the registered ANSiscope indices and hemodynamic variables. The correlation seen in this study suggests that the balANSindex^TM could be a useful tool to monitor ANS activity during anesthesia and surgery.

This article has been cited by other articles:

				G Schoffmann, P Winter, R Palme, A Pollak, G Trittenwein, and J Golej Haemodynamic changes and stress responses of piglets to surgery during total intravenous anaesthesia with propofol and fentanyl Lab Anim, July 1, 2009; 43(3): 243 - 248. [Abstract] [Full Text] [PDF]