JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hogue, C. W.
Right arrow Articles by Schechtman, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hogue, C. W., Jr
Right arrow Articles by Schechtman, K.

Anesth Analg 2006;102:1602-1608
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ANE.0000219591.10826.17


CARDIOVASCULAR ANESTHESIA

Preexisting Cognitive Impairment in Women Before Cardiac Surgery and Its Relationship with C-Reactive Protein Concentrations

Charles W. Hogue, Jr, MD, Tamara Hershey, PhD, David Dixon, PhD, Robert Fucetola, PhD, Abdullah Nassief, MD, Kenneth E. Freedland, PhD, Betsy Thomas, RN, and Kenneth Schechtman, PhD

Departments of Anesthesiology, Psychiatry, Neurology, Psychology, Radiology, and Biostatistics, Washington University School of Medicine, St. Louis, Missouri

Address correspondence to Charles W. Hogue, Jr., MD Department of Anesthesiology and Critical Care Med Johns Hopkins Hospital 600 N. Wolfe St, Tower 711 Baltimore, MD 21287–8711. Address e-mail to chogue2{at}jhmi.edu.

Preoperative cognitive state is seldom considered when investigating the effects of cardiac surgery on cognition. In this study we sought to determine the prevalence of cognitive impairment in women scheduled for cardiac surgery using nonhospitalized volunteers as a reference group and to examine the relationship between C-reactive protein levels and cognitive impairment. Psychometric testing was performed in 108 postmenopausal women scheduled for cardiac surgery and in 58 nonhospitalized control women. High sensitivity C-reactive protein levels were measured in the surgical patients. Preoperative cognitive impairment was defined as >2 sd lower scores on ≥2 tests compared with the controls. Cognitive impairment was present in 49 of 108 (45%) patients. C-reactive protein levels were higher for patients with compared with those without cognitive impairment (median, 8.1 mg/L versus 4.7 mg/L; P = 0.04). Based on multivariate logistic regression analysis, patient age, lower attained level of education, type 2 diabetes mellitus, and prior myocardial infarction identified risk for cognitive impairment (P < 0.05) but C-reactive protein levels did not (P = 0.09). In conclusion, cognitive impairment is prevalent in women before cardiac surgery. C-reactive protein levels are increased in women with this condition but the relationship between this inflammatory marker and preexisting cognitive impairment is likely secondary to the acute phase reactant serving as a marker for other predisposing conditions.




This article has been cited by other articles:


Home page
Ann. Thorac. Surg.Home page
B. S. Silbert, L. A. Evered, D. A. Scott, and T. F. Cowie
The Apolipoprotein E {epsilon}4 Allele is not Associated With Cognitive Dysfunction in Cardiac Surgery
Ann. Thorac. Surg., September 1, 2008; 86(3): 841 - 847.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
C. W. Hogue, R. Fucetola, T. Hershey, K. Freedland, V. G. Davila-Roman, A. M. Goate, and R. E. Thompson
Risk factors for neurocognitive dysfunction after cardiac surgery in postmenopausal women.
Ann. Thorac. Surg., August 1, 2008; 86(2): 511 - 516.
[Abstract] [Full Text] [PDF]


Home page
Anesth. Analg.Home page
C. W. Hogue Jr, R. Fucetola, T. Hershey, A. Nassief, S. Birge, V. G. Davila-Roman, B. Barzilai, B. Thomas, K. B. Schechtman, and K. Freedland
The Role of Postoperative Neurocognitive Dysfunction on Quality of Life for Postmenopausal Women 6 Months After Cardiac Surgery
Anesth. Analg., July 1, 2008; 107(1): 21 - 28.
[Abstract] [Full Text] [PDF]


Home page
StrokeHome page
C. W. Hogue Jr, K. Freedland, T. Hershey, R. Fucetola, A. Nassief, B. Barzilai, B. Thomas, S. Birge, D. Dixon, K. B. Schechtman, et al.
Neurocognitive Outcomes Are Not Improved by 17{beta}-Estradiol in Postmenopausal Women Undergoing Cardiac Surgery
Stroke, July 1, 2007; 38(7): 2048 - 2054.
[Abstract] [Full Text] [PDF]


Home page
Anesth. Analg.Home page
C. W. Hogue, O. A. Selnes, and G. McKhann
Should All Patients Undergoing Cardiac Surgery Have Preoperative Psychometric Testing: A Brain Stress Test?
Anesth. Analg., May 1, 2007; 104(5): 1012 - 1014.
[Full Text] [PDF]


Home page
Anesth. Analg.Home page
B. S. Silbert, D. A. Scott, L. A. Evered, M. S. Lewis, and P. T. Maruff
Preexisting Cognitive Impairment in Patients Scheduled for Elective Coronary Artery Bypass Graft Surgery
Anesth. Analg., May 1, 2007; 104(5): 1023 - 1028.
[Abstract] [Full Text] [PDF]




Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.