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ANESTHETIC PHARMACOLOGY

The Effects of Xenon on Myogenic Motor Evoked Potentials in Rabbits: A Comparison with Propofol and Isoflurane

Department of Anesthesiology, Nara Medical University, Nara, Japan; Department of Anesthesia, Teikyo University, School of Medicine, Tokyo, Japan

Address correspondence and reprint requests to Masahiko Kawaguchi, MD, Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Nara, Japan. Address e-mail to drjkawa{at}naramed-u.ac.jp.

We compared the effects of xenon on myogenic motor evoked potentials (MEPs) with those of propofol and isoflurane in rabbits under ketamine/fentanyl anesthesia. Thirty animals were randomly allocated to one of 3 groups (n = 10 in each group). In the propofol group, propofol was administered at a rate of 0.4 mg · kg^–1 · min^–1 (small) and 0.8 mg · kg^–1 · min^–1 (large). In the isoflurane group, isoflurane was administered at 0.8% (small) and 1.6% (large). In the xenon group, xenon was administered at 35% (small) and 70% (large). Myogenic MEPs in response to stimulation with single pulse and a train of 5 pulses were recorded from the soleus muscle before, during (at small and large doses), and after the administration of each anesthetic. With single-pulse stimulation, MEPs were recorded in 90% and 50% of animals at small and large doses of xenon, respectively, and MEP amplitudes in the xenon and isoflurane groups were significantly lower compared with those in the propofol group. With train pulse stimulation, MEPs were recorded in 100% and 90% of animals at small and large doses of xenon, respectively, and a reduction in MEP amplitudes by xenon was more prominent than by propofol but less than isoflurane at large doses. These results suggest that MEP recording may be feasible under xenon anesthesia if multipulse stimulation is used, although xenon has suppressive effects on myogenic MEPs.

This article has been cited by other articles:

				H. Hayashi, M. Kawaguchi, Y. Yamamoto, S. Inoue, M. Koizumi, Y. Ueda, Y. Takakura, and H. Furuya The Application of Tetanic Stimulation of the Unilateral Tibial Nerve Before Transcranial Stimulation Can Augment the Amplitudes of Myogenic Motor-Evoked Potentials from the Muscles in the Bilateral Upper and Lower Limbs Anesth. Analg., July 1, 2008; 107(1): 215 - 220. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999