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Anesth Analg 2006;102:1830-1835
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000205739.37190.14

NEUROSURGICAL ANESTHESIA

The Effect of Desflurane and Sevoflurane on Cerebral Oximetry Under Steady-State Conditions

Argyro Fassoulaki, MD, PhD, DEAA, Helen Kaliontzi, MD, George Petropoulos, MD, and Athanassia Tsaroucha, MD

Department of Anesthesiology, Aretaieion Hospital, Athens, Greece

Address correspondence and reprint requests to Argyro Fassoulaki MD, PhD, DEAA, 57-59 Raftopoulou Street, 11744 Athens, Greece. Address e-mail to afassou1{at}otenet.gr or fassoula{at}aretaieio.uoa.gr.

We studied the effect of sevoflurane and desflurane on regional cerebral oxygenation (rSO2). Twenty-two patients undergoing abdominal hysterectomy received sevoflurane and desflurane for 15 min each and 30 min apart under steady-state conditions in a randomized, crossover manner to maintain a bispectral index (BIS) of 40–50. In another 22 patients undergoing the same anesthesia and surgery BIS was maintained at 20–30. During the 15-min administration of each anesthetic at steady-state conditions rSO2, BIS, inspired and end-tidal anesthetic concentrations, end-tidal CO2, Spo2, systolic and diastolic blood pressures, and heart rate were recorded every 3 min. The rSO2 did not differ between sevoflurane and desflurane when BIS values were maintained between 40–50 or 20–30. The MACBIS values required to maintain BIS at 40–50 and at 20–30 were 1.0 versus 1.2 (P = 0.004) and 1.6 versus 1.8 (P < 0.001) for desflurane and sevoflurane respectively. Higher rSO2 values were obtained by 1.6 MAC (71 ± 13) than by 1 MAC of desflurane (66 ± 10; P < 0.001) and by 1.8 MAC (72 ± 11) than by 1.2 MAC of sevoflurane (66 ± 13; P < 0.001). In conclusion, equipotent concentrations of desflurane or sevoflurane in terms of BIS are associated with similar rSO2 values, but larger anesthetic concentrations of both anesthetics increased the rSO2 values.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.