JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Capuzzo, M.
Right arrow Articles by Alvisi, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Capuzzo, M.
Right arrow Articles by Alvisi, R.
Related Collections
Right arrow Pharmacology

Anesth Analg 2006;103:121-123
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000222476.62547.ed

ANESTHETIC PHARMACOLOGY

Melatonin Does Not Reduce Anxiety More than Placebo in the Elderly Undergoing Surgery

Maurizia Capuzzo, MD*, Barbara Zanardi, MD*, Elisa Schiffino, MD*, Cosimetta Buccoliero, MD*, Daniela Gragnaniello, MD{dagger}, Stefano Bianchi, PhD{ddagger}, and Raffaele Alvisi, MD*

From the *Department of Surgical, Anesthetic and Radiological Sciences. Section of Anesthesiology and Intensive Care, {dagger}Department of Neurosciences, Section of Neurology, and {ddagger}Department of Pharmacy, University Hospital of Ferrara, Ferrara, Italy.

Address correspondence and reprint requests to Maurizia Capuzzo, MD, Dipartimento di Scienze Chirurgiche, Anestesiologiche e Radiologiche Sezione di Anestesia e Rianimazione Azienda Ospedaliera S. Anna Corso Giovecca 203, 44100 Ferrara, Italy. Address e-mail to cpm{at}unife.it.

Melatonin has been reported to reduce preoperative anxiety. We performed this study to compare preoperative anxiety in elderly patients receiving melatonin (M) or placebo (P). Anxiety was measured in patients aged >65 yr by a numerical rating scale (range, 0–10). Each patient was randomized to receive M 10 mg or P orally: 71 patients were in group P and 67 in group M. The median (quartiles) anxiety level was 5 (2–8) before and 3 (1–7) 90 min after premedication in group M and 5 (3–6) and 3 (1–5) in group P, respectively. M and P reduce anxiety in elderly patients to a similar degree.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
H. A. Mowafi and S. A. Ismail
Melatonin Improves Tourniquet Tolerance and Enhances Postoperative Analgesia in Patients Receiving Intravenous Regional Anesthesia
Anesth. Analg., October 1, 2008; 107(4): 1422 - 1426.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
R. Chenevard, Y. Suter, and P. Erne
Effects of the heart-lung machine on melatonin metabolism and mood disturbances.
Eur. J. Cardiothorac. Surg., August 1, 2008; 34(2): 338 - 343.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
W. Caumo, F. Torres, N. L. Moreira Jr, J. A. S. Auzani, C. A. Monteiro, G. Londero, D. F. M. Ribeiro, and M. P. L. Hidalgo
The Clinical Impact of Preoperative Melatonin on Postoperative Outcomes in Patients Undergoing Abdominal Hysterectomy
Anesth. Analg., November 1, 2007; 105(5): 1263 - 1271.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.