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CARDIOVASCULAR ANESTHESIA

Perioperative Management of a Heterozygous Carrier of Glanzmann’s Thrombasthenia Submitted to Coronary Artery Bypass Grafting With Cardiopulmonary Bypass

Valter Casati, MD^*, Armando D’Angelo, MD, Luciano Barbato, MD, Edoardo Rossi, MD, Maria Antonietta Grasso, MD^*, Salvatore Spagnolo, MD, and Ezio Panzeri, MD

From the *Division of Cardiovascular Anesthesia and Intensive Care, Policlinico di Monza, Monza, Italy; Coagulation Service and Thrombosis Research Unit, Ospedale San Raffaele, Milano, Italy; Division of Cardiac Surgery, Policlinico di Monza, Monza, Italy; Division of Hematology, Ospedale Sacco, Milano, Italy.

Address correspondence and reprint requests to Valter Casati, MD, Division of Cardiovascular Anesthesia and Intensive Care, Policlinico di Monza, via Amati 111, Monza (20052), Italy. Address e-mail to valter.casati{at}policlinicodimonza.it.

Glanzmann’s thrombasthenia is a congenital hemorrhagic disorder transmitted as an autosomal recessive trait and characterized by altered production and/or assembly of the platelet membrane glycoprotein IIb/IIIa receptor. We describe the perioperative management of a heterozygous carrier of Glanzmann’s thrombasthenia submitted to cardiac surgery with cardiopulmonary bypass and the case was complicated by early excessive postoperative bleeding.