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Anesth Analg 2006;103:478-483
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000223847.50233.1b

PAIN MEDICINE

Propofol’s Effects on Nociceptive Behavior and Spinal C-Fos Expression After Intraplantar Formalin Injection in Mice with a Mutation in the Gamma-Aminobutyric Acid-TypeA Receptor ß3 Subunit

Austin W. Merrill, BS*, Linda S. Barter, MVS{dagger}, Uwe Rudolph, MD{ddagger}, Edmond I. Eger, II, MD§, Joseph F. Antognini, MD*{dagger}, Mirela Iodi Carstens, BA*, and E. Carstens, PhD*

From the *Section of Neurobiology, Physiology and Behavior, {dagger}Department of Anesthesiology and Pain Medicine, University of California, Davis, California; {ddagger}McLean Hospital, Belmont, Massachusetts; and the §Department of Anesthesiology and Perioperative Care, University of California, San Francisco, San Francisco, California.

Address correspondence and reprint requests to Earl E. Carstens, Section of Neurobiology, Physiology & Behavior, University of California, Davis, Davis, California, 95616. E-mail: eecarstens{at}ucdavis.edu.

We investigated whether propofol affected nociceptive behavior and fos-like immunoreactivity (FLI) in the lumbo-sacral spinal cord after intraplantar formalin injection in wild-type (WT) mice and in mutant mice harboring a point mutation of the gamma-aminobutyric acid type A receptor, which renders them resistant to propofol. Bolus injection of propofol (30 mg/kg IV) in WT mice reduced phase 1 formalin-evoked behavior over the initial 2–3 min but did not alter phase 2 behavior or spinal FLI (64 ± 19 cells/section) compared with WT mice receiving intralipid vehicle plus intraplantar formalin (57 ± 19 cells/section). Most FLI was restricted to superficial dorsal horn laminae ipsilateral to the formalin injection. WT mice receiving a 60-min propofol infusion were anesthetized throughout and did not display nociceptive behavior but had FLI (58 ± 11 cells/section) that did not differ significantly from the other WT groups. Mutant mice receiving bolus injection of propofol (30 mg/kg) and intraplantar formalin were not anesthetized and exhibited nociceptive behavior. The total FLI in the spinal cord was 47 ± 29 cells/section. These data indicate that although propofol produces anesthesia, it does not prevent the FLI that is associated with nociception, a finding consistent with propofol lacking analgesic properties.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.